Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS
A rapid and sensitive ultrafast performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) was developed for the simultaneous determination of 11 compounds in Gualou Guizhi Granule (GLGZG), including liquiritin, isoliquiritin, liquirtin apioside, isoliquiritin apioside, liquiriti...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/8451383 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849700817604444160 |
|---|---|
| author | Chengtao Sun Wen Xu Yuqin Zhang Lishuang Yu Miao Ye Kedan Chu Wei Xu Yu Lin |
| author_facet | Chengtao Sun Wen Xu Yuqin Zhang Lishuang Yu Miao Ye Kedan Chu Wei Xu Yu Lin |
| author_sort | Chengtao Sun |
| collection | DOAJ |
| description | A rapid and sensitive ultrafast performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) was developed for the simultaneous determination of 11 compounds in Gualou Guizhi Granule (GLGZG), including liquiritin, isoliquiritin, liquirtin apioside, isoliquiritin apioside, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, glycyrrhetinic acid, paeoniflorin, albiflorin, and paeoniflorin sulfonate in rat plasma. UPLC-MS/MS assay with negative ion mode was performed on a Waters CORTECS C18 (2.1 × 100 mm, 1.6 μm) with the mobile phase consisting of 0.1% aqueous formic acid (A) and acetonitrile (B) in gradient elution at a flow rate of 0.25 mL·min−1. The method was linear for all analytes within the detection range (r≥0.9597). The inter- and intraday precision (RSD) were 2.21–6.41% and 1.67–6.18%; the inter- and intraday accuracy (recover) were 92.48–114.03% and 90.23–112.04%. And the recovery rate ranged from 81.30% to 108.22%. The matrix effect values obtained for analytes ranged from 88.91% to 113.32%. This validated method was successfully applied to a pharmacokinetics study in rats after oral administration of GLGZG. |
| format | Article |
| id | doaj-art-65a635e748914a2ba914c875e50046a4 |
| institution | DOAJ |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-65a635e748914a2ba914c875e50046a42025-08-20T03:18:09ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732017-01-01201710.1155/2017/84513838451383Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MSChengtao Sun0Wen Xu1Yuqin Zhang2Lishuang Yu3Miao Ye4Kedan Chu5Wei Xu6Yu Lin7College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, ChinaA rapid and sensitive ultrafast performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) was developed for the simultaneous determination of 11 compounds in Gualou Guizhi Granule (GLGZG), including liquiritin, isoliquiritin, liquirtin apioside, isoliquiritin apioside, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, glycyrrhetinic acid, paeoniflorin, albiflorin, and paeoniflorin sulfonate in rat plasma. UPLC-MS/MS assay with negative ion mode was performed on a Waters CORTECS C18 (2.1 × 100 mm, 1.6 μm) with the mobile phase consisting of 0.1% aqueous formic acid (A) and acetonitrile (B) in gradient elution at a flow rate of 0.25 mL·min−1. The method was linear for all analytes within the detection range (r≥0.9597). The inter- and intraday precision (RSD) were 2.21–6.41% and 1.67–6.18%; the inter- and intraday accuracy (recover) were 92.48–114.03% and 90.23–112.04%. And the recovery rate ranged from 81.30% to 108.22%. The matrix effect values obtained for analytes ranged from 88.91% to 113.32%. This validated method was successfully applied to a pharmacokinetics study in rats after oral administration of GLGZG.http://dx.doi.org/10.1155/2017/8451383 |
| spellingShingle | Chengtao Sun Wen Xu Yuqin Zhang Lishuang Yu Miao Ye Kedan Chu Wei Xu Yu Lin Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS Journal of Analytical Methods in Chemistry |
| title | Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS |
| title_full | Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS |
| title_fullStr | Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS |
| title_full_unstemmed | Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS |
| title_short | Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS |
| title_sort | simultaneous determination of 11 compounds in gualou guizhi granule and pharmacokinetics study by uplc ms ms |
| url | http://dx.doi.org/10.1155/2017/8451383 |
| work_keys_str_mv | AT chengtaosun simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms AT wenxu simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms AT yuqinzhang simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms AT lishuangyu simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms AT miaoye simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms AT kedanchu simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms AT weixu simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms AT yulin simultaneousdeterminationof11compoundsingualouguizhigranuleandpharmacokineticsstudybyuplcmsms |