Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats
The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates (SCGH) in a rat model of type II diabetes induced by streptozotocin (STZ) combined with high-fat diet (HFD). Results showed that SCGH significantly reduced water intake, fasting bloo...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022001033 |
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| author | Tingting Wang Lin Zheng Shuguang Wang Mouming Zhao Xiaoling Liu |
| author_facet | Tingting Wang Lin Zheng Shuguang Wang Mouming Zhao Xiaoling Liu |
| author_sort | Tingting Wang |
| collection | DOAJ |
| description | The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates (SCGH) in a rat model of type II diabetes induced by streptozotocin (STZ) combined with high-fat diet (HFD). Results showed that SCGH significantly reduced water intake, fasting blood glucose level and glycated hemoglobin level. Moreover, the oral glucose tolerance, insulin resistance and plasma lipid level in diabetic rats were also alleviated. Furthermore, histological analysis showed that SCGH effectively protected the tissue structure of liver. In addition, mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway, and promoted lipid metabolism via activating the AMPK signaling pathway. In summary, these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders. |
| format | Article |
| id | doaj-art-65a544d2924543d8815e5772cbe336bc |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-65a544d2924543d8815e5772cbe336bc2025-02-03T06:56:02ZengTsinghua University PressFood Science and Human Wellness2213-45302022-11-0111616141622Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic ratsTingting Wang0Lin Zheng1Shuguang Wang2Mouming Zhao3Xiaoling Liu4College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, ChinaGuangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, ChinaGuangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, ChinaCollege of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, Guangzhou 510650, China; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Corresponding authors at: College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, ChinaCollege of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China; Corresponding authors at: College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, ChinaThe present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates (SCGH) in a rat model of type II diabetes induced by streptozotocin (STZ) combined with high-fat diet (HFD). Results showed that SCGH significantly reduced water intake, fasting blood glucose level and glycated hemoglobin level. Moreover, the oral glucose tolerance, insulin resistance and plasma lipid level in diabetic rats were also alleviated. Furthermore, histological analysis showed that SCGH effectively protected the tissue structure of liver. In addition, mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway, and promoted lipid metabolism via activating the AMPK signaling pathway. In summary, these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders.http://www.sciencedirect.com/science/article/pii/S2213453022001033Sea cucumber gonadBioactive peptideAnti-diabetic activityInsulin resistance |
| spellingShingle | Tingting Wang Lin Zheng Shuguang Wang Mouming Zhao Xiaoling Liu Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats Food Science and Human Wellness Sea cucumber gonad Bioactive peptide Anti-diabetic activity Insulin resistance |
| title | Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats |
| title_full | Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats |
| title_fullStr | Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats |
| title_full_unstemmed | Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats |
| title_short | Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats |
| title_sort | anti diabetic and anti hyperlipidemic effects of sea cucumber cucumaria frondosa gonad hydrolysates in type ii diabetic rats |
| topic | Sea cucumber gonad Bioactive peptide Anti-diabetic activity Insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022001033 |
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