MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATH
The literary review focuses on the dysfunction of endoplasmic reticulum (EPR), the role of EPR stress and oxidative stress in the pathogenesis of optic nerve damage. The data on the molecular mechanisms of optic nerve damage are given: these include the expression of genes and molecular chaperones,...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2018-10-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/177 |
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| author | V. V. Neroev T. N. Kiseleva Ì. S. Zaitsev |
| author_facet | V. V. Neroev T. N. Kiseleva Ì. S. Zaitsev |
| author_sort | V. V. Neroev |
| collection | DOAJ |
| description | The literary review focuses on the dysfunction of endoplasmic reticulum (EPR), the role of EPR stress and oxidative stress in the pathogenesis of optic nerve damage. The data on the molecular mechanisms of optic nerve damage are given: these include the expression of genes and molecular chaperones, which are related to EPR stress and antioxidant protection. The studies into oral administration of bilberry extract anthocyanosides showed elevated levels of molecular chaperones in retinal ganglion cells (RGC). The chaperones suppress EPR stress and produce a positive effect on the metabolic activity of the cells. Thus, bilberry extract anthocyanosides may be considered as neuroprotectors in combined treatment of retinal pathology and glaucoma. For citation: Neroev V.V., Kiseleva T.N., Zaitsev М.S. Molecular mechanisms of optic nerve damage: the role of anthocyanozides in the prevention of retinal ganglion cell death. Russian ophthalmological journal. 2018; 11 (3): 101-6 (In Russian). doi: 10.21516/2072-0076-2018-11-3-101-106 |
| format | Article |
| id | doaj-art-65a3b64731364c86918c8a123b84de5b |
| institution | DOAJ |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-65a3b64731364c86918c8a123b84de5b2025-08-20T03:19:24ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602018-10-0111310110610.21516/2072-0076-2018-11-3-101-106177MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATHV. V. Neroev0T. N. Kiseleva1Ì. S. Zaitsev2Moscow Helmholtz Research Institute of Eye Diseases, RussiaMoscow Helmholtz Research Institute of Eye Diseases, RussiaMoscow Helmholtz Research Institute of Eye Diseases, RussiaThe literary review focuses on the dysfunction of endoplasmic reticulum (EPR), the role of EPR stress and oxidative stress in the pathogenesis of optic nerve damage. The data on the molecular mechanisms of optic nerve damage are given: these include the expression of genes and molecular chaperones, which are related to EPR stress and antioxidant protection. The studies into oral administration of bilberry extract anthocyanosides showed elevated levels of molecular chaperones in retinal ganglion cells (RGC). The chaperones suppress EPR stress and produce a positive effect on the metabolic activity of the cells. Thus, bilberry extract anthocyanosides may be considered as neuroprotectors in combined treatment of retinal pathology and glaucoma. For citation: Neroev V.V., Kiseleva T.N., Zaitsev М.S. Molecular mechanisms of optic nerve damage: the role of anthocyanozides in the prevention of retinal ganglion cell death. Russian ophthalmological journal. 2018; 11 (3): 101-6 (In Russian). doi: 10.21516/2072-0076-2018-11-3-101-106https://roj.igb.ru/jour/article/view/177стресс эндоплазматического ретикулумаокислительный стрессмолекулярные шапероныганглиозные клетки сетчаткизрительный нервантоцианозидыendoplasmic reticulum stressoxidative stressmolecular chaperonesretinal ganglion cellsoptic nerveanthocyanoisides |
| spellingShingle | V. V. Neroev T. N. Kiseleva Ì. S. Zaitsev MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATH Российский офтальмологический журнал стресс эндоплазматического ретикулума окислительный стресс молекулярные шапероны ганглиозные клетки сетчатки зрительный нерв антоцианозиды endoplasmic reticulum stress oxidative stress molecular chaperones retinal ganglion cells optic nerve anthocyanoisides |
| title | MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATH |
| title_full | MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATH |
| title_fullStr | MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATH |
| title_full_unstemmed | MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATH |
| title_short | MOLECULAR MECHANISMS OF OPTIC NERVE DAMAGE: THE ROLE OF ANTHOCYANOZIDES IN THE PREVENTION OF RETINAL GANGLION CELL DEATH |
| title_sort | molecular mechanisms of optic nerve damage the role of anthocyanozides in the prevention of retinal ganglion cell death |
| topic | стресс эндоплазматического ретикулума окислительный стресс молекулярные шапероны ганглиозные клетки сетчатки зрительный нерв антоцианозиды endoplasmic reticulum stress oxidative stress molecular chaperones retinal ganglion cells optic nerve anthocyanoisides |
| url | https://roj.igb.ru/jour/article/view/177 |
| work_keys_str_mv | AT vvneroev molecularmechanismsofopticnervedamagetheroleofanthocyanozidesinthepreventionofretinalganglioncelldeath AT tnkiseleva molecularmechanismsofopticnervedamagetheroleofanthocyanozidesinthepreventionofretinalganglioncelldeath AT iszaitsev molecularmechanismsofopticnervedamagetheroleofanthocyanozidesinthepreventionofretinalganglioncelldeath |