PHYOX3: Nedosiran Long-Term Safety and Efficacy in Patients With Primary Hyperoxaluria Type 1

PHYOX3: Nedosiran Long-Term Safety and Efficacy in Patients With Primary Hyperoxaluria Type 1

Introduction: Primary hyperoxaluria type 1 (PH1) is a rare genetic disease characterized by oxalate overproduction in the liver, leading to hyperoxaluria, calcium oxalate stones, nephrocalcinosis, progressive chronic kidney damage, kidney failure, and systemic oxalate deposition. Nedosiran, an RNA i...

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Main Authors: John C. Lieske, Gema Ariceta, Jaap W. Groothoff, Graham Lipkin, Shabbir H. Moochhala, Gesa Schalk, Anne-Laure Sellier-Leclerc, Sara Estupiñan Torres, Verity Rawson, Jing Zhou, Bernd Hoppe
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Kidney International Reports
Subjects:
eGFR
kidney stones
long-term treatment
primary hyperoxaluria
urinary oxalate
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024925001743
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