Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations

Measurements of serum insulin-like growth factor 1 (IGF-1) levels are useful surrogate markers for the diagnosis and management of patients with growth hormone-related disorders. We have previously published normative data of serum IGF-1 levels for the Japanese population aged 0–77 years by combinin...

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Main Authors: Tsuyoshi Isojima, Akira Shimatsu
Format: Article
Language:English
Published: The Japan Endocrine Society 2023-10-01
Series:Endocrine Journal
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Online Access:https://www.jstage.jst.go.jp/article/endocrj/70/10/70_EJ23-0274/_html/-char/en
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author Tsuyoshi Isojima
Akira Shimatsu
author_facet Tsuyoshi Isojima
Akira Shimatsu
author_sort Tsuyoshi Isojima
collection DOAJ
description Measurements of serum insulin-like growth factor 1 (IGF-1) levels are useful surrogate markers for the diagnosis and management of patients with growth hormone-related disorders. We have previously published normative data of serum IGF-1 levels for the Japanese population aged 0–77 years by combining and analyzing previously reported references, which were separately and independently constructed, to properly reflect data in the transition period. Although the reference is widely used in both clinical and research settings, the reference did not include data for those aged >77 years, raising the question of how we would evaluate patients over those ages. In this study, we extended the age- and sex-specific reference ranges of serum IGF-1 levels to the age of 80 years by reanalyzing combined data on serum IGF-1 levels from previously published references. Based on our results, we proposed that individuals aged >80 years can be evaluated using the references set at the age of 80 years. However, our proposal was based on a very limited number of participants. Therefore, physicians should exercise caution when interpreting IGF-1 standard deviation scores for those aged >80 years because they are not exactly correct but acceptable.
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spelling doaj-art-6596755fdddd418fba76aa44c2ad46732025-01-22T06:19:21ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402023-10-0170101023102710.1507/endocrj.EJ23-0274endocrjProposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populationsTsuyoshi Isojima0Akira Shimatsu1GH and its Related Factors Study Committee and GH Treatment Study Committee, The Foundation for Growth Science in Japan, Tokyo 113-0033, JapanGH and its Related Factors Study Committee and GH Treatment Study Committee, The Foundation for Growth Science in Japan, Tokyo 113-0033, JapanMeasurements of serum insulin-like growth factor 1 (IGF-1) levels are useful surrogate markers for the diagnosis and management of patients with growth hormone-related disorders. We have previously published normative data of serum IGF-1 levels for the Japanese population aged 0–77 years by combining and analyzing previously reported references, which were separately and independently constructed, to properly reflect data in the transition period. Although the reference is widely used in both clinical and research settings, the reference did not include data for those aged >77 years, raising the question of how we would evaluate patients over those ages. In this study, we extended the age- and sex-specific reference ranges of serum IGF-1 levels to the age of 80 years by reanalyzing combined data on serum IGF-1 levels from previously published references. Based on our results, we proposed that individuals aged >80 years can be evaluated using the references set at the age of 80 years. However, our proposal was based on a very limited number of participants. Therefore, physicians should exercise caution when interpreting IGF-1 standard deviation scores for those aged >80 years because they are not exactly correct but acceptable.https://www.jstage.jst.go.jp/article/endocrj/70/10/70_EJ23-0274/_html/-char/eninsulin-like growth factor-1reference intervalsolder peoplejapanese population
spellingShingle Tsuyoshi Isojima
Akira Shimatsu
Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations
Endocrine Journal
insulin-like growth factor-1
reference intervals
older people
japanese population
title Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations
title_full Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations
title_fullStr Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations
title_full_unstemmed Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations
title_short Proposed reference intervals of serum insulin-like growth factor-1 (IGF-1) levels in older Japanese populations
title_sort proposed reference intervals of serum insulin like growth factor 1 igf 1 levels in older japanese populations
topic insulin-like growth factor-1
reference intervals
older people
japanese population
url https://www.jstage.jst.go.jp/article/endocrj/70/10/70_EJ23-0274/_html/-char/en
work_keys_str_mv AT tsuyoshiisojima proposedreferenceintervalsofseruminsulinlikegrowthfactor1igf1levelsinolderjapanesepopulations
AT akirashimatsu proposedreferenceintervalsofseruminsulinlikegrowthfactor1igf1levelsinolderjapanesepopulations