Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis
Objective The fibrinogen/albumin ratio (FAR) is a novel inflammatory indicator, which has been associated with cardiovascular disease. However, the relationship between FAR and cardiovascular event (CVE) in patients with peritoneal dialysis (PD) remains unclear. This study aims to clarify the relati...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2499025 |
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| author | Qiqi Yan Guiling Liu Ruifeng Wang Dandan Li Deguang Wang |
| author_facet | Qiqi Yan Guiling Liu Ruifeng Wang Dandan Li Deguang Wang |
| author_sort | Qiqi Yan |
| collection | DOAJ |
| description | Objective The fibrinogen/albumin ratio (FAR) is a novel inflammatory indicator, which has been associated with cardiovascular disease. However, the relationship between FAR and cardiovascular event (CVE) in patients with peritoneal dialysis (PD) remains unclear. This study aims to clarify the relationship between FAR and first-ever CVE in patients with PD.Methods A total of 278 patients were enrolled between January 2012 and June 2021. They were defined as the high FAR group and the low FAR group based on the median FAR value (0.107). The primary outcome was the occurrence of first-ever CVE. Kaplan–Meier’s curves and Cox regression analysis were used to analyse the relationship between FAR and first-ever CVE in patients with PD. Forest plots were employed to depict the relationship between FAR and first-ever CVE in each subgroup.Results The average follow-up period was 40.26 ± 28.27 months. A total of 101 (36.3%) patients developed first-ever CVE. Kaplan–Meier’s analysis showed that there was a higher risk of first-ever CVE (p = .002) in the high FAR group. Multivariate Cox regression analysis showed that FAR ≥ 0.107 and age were independently associated with the risk of first-ever CVE in patients with PD. Receiver operating characteristic (ROC) analysis showed that FAR had a greater predicting value on the first-ever CVE.Conclusions High levels of FAR are independently associated with an increased risk of first-ever CVE in patients with PD. |
| format | Article |
| id | doaj-art-65943a98102d43189a98d25ba5670721 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-65943a98102d43189a98d25ba56707212025-08-20T02:14:01ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2499025Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysisQiqi Yan0Guiling Liu1Ruifeng Wang2Dandan Li3Deguang Wang4Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaObjective The fibrinogen/albumin ratio (FAR) is a novel inflammatory indicator, which has been associated with cardiovascular disease. However, the relationship between FAR and cardiovascular event (CVE) in patients with peritoneal dialysis (PD) remains unclear. This study aims to clarify the relationship between FAR and first-ever CVE in patients with PD.Methods A total of 278 patients were enrolled between January 2012 and June 2021. They were defined as the high FAR group and the low FAR group based on the median FAR value (0.107). The primary outcome was the occurrence of first-ever CVE. Kaplan–Meier’s curves and Cox regression analysis were used to analyse the relationship between FAR and first-ever CVE in patients with PD. Forest plots were employed to depict the relationship between FAR and first-ever CVE in each subgroup.Results The average follow-up period was 40.26 ± 28.27 months. A total of 101 (36.3%) patients developed first-ever CVE. Kaplan–Meier’s analysis showed that there was a higher risk of first-ever CVE (p = .002) in the high FAR group. Multivariate Cox regression analysis showed that FAR ≥ 0.107 and age were independently associated with the risk of first-ever CVE in patients with PD. Receiver operating characteristic (ROC) analysis showed that FAR had a greater predicting value on the first-ever CVE.Conclusions High levels of FAR are independently associated with an increased risk of first-ever CVE in patients with PD.https://www.tandfonline.com/doi/10.1080/07853890.2025.2499025Cardiovascular eventchronic kidney diseasefibrinogen/albumin ratioinflammationperitoneal dialysis |
| spellingShingle | Qiqi Yan Guiling Liu Ruifeng Wang Dandan Li Deguang Wang Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis Annals of Medicine Cardiovascular event chronic kidney disease fibrinogen/albumin ratio inflammation peritoneal dialysis |
| title | Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis |
| title_full | Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis |
| title_fullStr | Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis |
| title_full_unstemmed | Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis |
| title_short | Fibrinogen/albumin ratio is associated with first-ever cardiovascular events in patients with peritoneal dialysis |
| title_sort | fibrinogen albumin ratio is associated with first ever cardiovascular events in patients with peritoneal dialysis |
| topic | Cardiovascular event chronic kidney disease fibrinogen/albumin ratio inflammation peritoneal dialysis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2499025 |
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