Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1
Neurotrophic keratitis (also called neurotrophic keratopathy) (NTK) is a degenerative disease of the cornea, accompanied with neurogenic inflammation. It caused by a sensitive innervation loss of the trigeminal nerve and characterized by reduced sensitivity of the cornea and a retardation of its hea...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2022-04-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/1768 |
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| author | E. A. Kasparova N. R. Marchenko |
| author_facet | E. A. Kasparova N. R. Marchenko |
| author_sort | E. A. Kasparova |
| collection | DOAJ |
| description | Neurotrophic keratitis (also called neurotrophic keratopathy) (NTK) is a degenerative disease of the cornea, accompanied with neurogenic inflammation. It caused by a sensitive innervation loss of the trigeminal nerve and characterized by reduced sensitivity of the cornea and a retardation of its healing process. NTC-causing damage to the trigeminal nerve can occur at different levels-from the nucleus to the terminals located in the cornea, and can be caused by ocular and systemic diseases both. The most common causes include herpetic keratitis, diabetes, chemical burns and iatrogenic injuries during ophthalmic operations, intracranial neoplasms, disorders of cerebral circulation and neurosurgical interventions. Corneal changes include epitheliopathy (grade I), persistent erosion (grade II), ulcer and its complications (grade III). The determining diagnostic sign of NTK is a decrease or loss of corneal sensitivity. The morphological characteristics of the corneal nerves can be studied using confocal microscopy. |
| format | Article |
| id | doaj-art-6593ec0b74b04fb89f841824f3520175 |
| institution | Kabale University |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2022-04-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-6593ec0b74b04fb89f841824f35201752025-08-20T04:00:25ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452022-04-01191384510.18008/1816-5095-2022-1-38-45860Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1E. A. Kasparova0N. R. Marchenko1Research Institute of Eye DiseasesResearch Institute of Eye DiseasesNeurotrophic keratitis (also called neurotrophic keratopathy) (NTK) is a degenerative disease of the cornea, accompanied with neurogenic inflammation. It caused by a sensitive innervation loss of the trigeminal nerve and characterized by reduced sensitivity of the cornea and a retardation of its healing process. NTC-causing damage to the trigeminal nerve can occur at different levels-from the nucleus to the terminals located in the cornea, and can be caused by ocular and systemic diseases both. The most common causes include herpetic keratitis, diabetes, chemical burns and iatrogenic injuries during ophthalmic operations, intracranial neoplasms, disorders of cerebral circulation and neurosurgical interventions. Corneal changes include epitheliopathy (grade I), persistent erosion (grade II), ulcer and its complications (grade III). The determining diagnostic sign of NTK is a decrease or loss of corneal sensitivity. The morphological characteristics of the corneal nerves can be studied using confocal microscopy.https://www.ophthalmojournal.com/opht/article/view/1768neurotrophic keratitisneurotrophic keratopathycorneal erosioncorneal ulcerneurogenic inflammationcorneal meltingcorneal nervesnerve growth factor |
| spellingShingle | E. A. Kasparova N. R. Marchenko Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1 Oftalʹmologiâ neurotrophic keratitis neurotrophic keratopathy corneal erosion corneal ulcer neurogenic inflammation corneal melting corneal nerves nerve growth factor |
| title | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1 |
| title_full | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1 |
| title_fullStr | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1 |
| title_full_unstemmed | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1 |
| title_short | Neurotrophic Keratitis. Etiology, Pathogenesis, Clinical Manifestations. Review. Part 1 |
| title_sort | neurotrophic keratitis etiology pathogenesis clinical manifestations review part 1 |
| topic | neurotrophic keratitis neurotrophic keratopathy corneal erosion corneal ulcer neurogenic inflammation corneal melting corneal nerves nerve growth factor |
| url | https://www.ophthalmojournal.com/opht/article/view/1768 |
| work_keys_str_mv | AT eakasparova neurotrophickeratitisetiologypathogenesisclinicalmanifestationsreviewpart1 AT nrmarchenko neurotrophickeratitisetiologypathogenesisclinicalmanifestationsreviewpart1 |