Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.

CHIP (carboxyl terminus of heat shock 70-interacting protein) has long been recognized as an active member of the cellular protein quality control system given the ability of CHIP to function as both a co-chaperone and ubiquitin ligase. We discovered a genetic disease, now known as spinocerebellar a...

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Main Authors: Chang-He Shi, Carrie Rubel, Sarah E Soss, Rebekah Sanchez-Hodge, Shuo Zhang, Sabrina C Madrigal, Saranya Ravi, Holly McDonough, Richard C Page, Walter J Chazin, Cam Patterson, Cheng-Yuan Mao, Monte S Willis, Hai-Yang Luo, Yu-Sheng Li, Donte A Stevens, Mi-Bo Tang, Pan Du, Yao-He Wang, Zheng-Wei Hu, Yu-Ming Xu, Jonathan C Schisler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007664
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