Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation
Background: Mitochondrial DNA (mtDNA) typing, based on nucleotide sequencing of the control regions (known as hypervariable Regions I and II), is utilized in forensic investigations, human migration studies, and population genetics research. The objective of this study is to estimate mitochondrial h...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Transplantation |
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| Online Access: | https://journals.lww.com/10.4103/ijot.ijot_76_24 |
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| author | Vikash Chandra Mishra Dinesh Chandra Ritu Sharma Avdhesh Pandey Vimarsh Raina |
| author_facet | Vikash Chandra Mishra Dinesh Chandra Ritu Sharma Avdhesh Pandey Vimarsh Raina |
| author_sort | Vikash Chandra Mishra |
| collection | DOAJ |
| description | Background:
Mitochondrial DNA (mtDNA) typing, based on nucleotide sequencing of the control regions (known as hypervariable Regions I and II), is utilized in forensic investigations, human migration studies, and population genetics research. The objective of this study is to estimate mitochondrial haplogroup distribution and frequencies among the North Indian population using an appropriate statistical tool.
Materials and Methods:
In this study, a total of 230 samples were included and analyzed using polymerase chain reaction, gel detection, and Sanger sequencing methodologies from the region of North India.
Results:
A total of 63 distinct haplogroups were identified. Among these, haplogroup M was the most prevalent (38.26%), followed by haplogroup U (25.22%) and R (9.57%). The information obtained from this study will contribute to the development of a mtDNA database for the Indian population.
Conclusion:
This database could be valuable for forensic investigations, human migration studies, and population genetics research. It also suggests that mtDNA analysis would be useful for establishing maternal relationships in solid organ transplants, particularly in India. |
| format | Article |
| id | doaj-art-65888aeb029640be822947ffbca69dc9 |
| institution | OA Journals |
| issn | 2212-0017 2212-0025 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj-art-65888aeb029640be822947ffbca69dc92025-08-20T02:11:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252025-01-01191586310.4103/ijot.ijot_76_24Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ TransplantationVikash Chandra MishraDinesh ChandraRitu SharmaAvdhesh PandeyVimarsh RainaBackground: Mitochondrial DNA (mtDNA) typing, based on nucleotide sequencing of the control regions (known as hypervariable Regions I and II), is utilized in forensic investigations, human migration studies, and population genetics research. The objective of this study is to estimate mitochondrial haplogroup distribution and frequencies among the North Indian population using an appropriate statistical tool. Materials and Methods: In this study, a total of 230 samples were included and analyzed using polymerase chain reaction, gel detection, and Sanger sequencing methodologies from the region of North India. Results: A total of 63 distinct haplogroups were identified. Among these, haplogroup M was the most prevalent (38.26%), followed by haplogroup U (25.22%) and R (9.57%). The information obtained from this study will contribute to the development of a mtDNA database for the Indian population. Conclusion: This database could be valuable for forensic investigations, human migration studies, and population genetics research. It also suggests that mtDNA analysis would be useful for establishing maternal relationships in solid organ transplants, particularly in India.https://journals.lww.com/10.4103/ijot.ijot_76_24mitochondrial dna analysismitochondrial haplogroupmitochondrial hypervariable i regionmitochondrial hypervariable ii region |
| spellingShingle | Vikash Chandra Mishra Dinesh Chandra Ritu Sharma Avdhesh Pandey Vimarsh Raina Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation Indian Journal of Transplantation mitochondrial dna analysis mitochondrial haplogroup mitochondrial hypervariable i region mitochondrial hypervariable ii region |
| title | Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation |
| title_full | Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation |
| title_fullStr | Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation |
| title_full_unstemmed | Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation |
| title_short | Mitochondrial DNA Haplogroups Frequency Analysis among North Indian Population: A Resource for Establishing Maternal Relationships in Solid Organ Transplantation |
| title_sort | mitochondrial dna haplogroups frequency analysis among north indian population a resource for establishing maternal relationships in solid organ transplantation |
| topic | mitochondrial dna analysis mitochondrial haplogroup mitochondrial hypervariable i region mitochondrial hypervariable ii region |
| url | https://journals.lww.com/10.4103/ijot.ijot_76_24 |
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