Molecular and subcellular mechanisms of vital macrophage extracellular trap formation

Molecular and subcellular mechanisms of vital macrophage extracellular trap formation

Macrophage extracellular traps (METs) are a poorly understood process beneficial for infection control but detrimental in inflammation, autoimmunity and cancer. Our research shows that viable macrophages release METs even when plasma membrane lysis is blocked. We demonstrate, for the first time, tha...

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Bibliographic Details
Main Authors: Yongchan Lee, Max Brenner, Monowar Aziz, Ping Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
macrophage extracellular trap
METs
vital
Gasdermin D
autophagy
LC3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1608428/full
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