Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome
Case Description. A 72-year-old woman with primary Sjögren Syndrome (SS) was diagnosed during an inpatient hospital stay with dry symptoms. The patient had respiratory and constitutional symptoms, requiring a pulmonary imaging evaluation by high-resolution computed tomography (HRCT) of the thorax. C...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2018/9745935 |
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| author | Gustavo Adolfo Gómez Correa Jovani Osorno Serna Manuel Felipe Cáceres Acosta Juan David Cáceres González Jaime Andrés Calle Ramirez Juan Paulo Sandoval Mesa Miguel Ignacio Roldán Pérez |
| author_facet | Gustavo Adolfo Gómez Correa Jovani Osorno Serna Manuel Felipe Cáceres Acosta Juan David Cáceres González Jaime Andrés Calle Ramirez Juan Paulo Sandoval Mesa Miguel Ignacio Roldán Pérez |
| author_sort | Gustavo Adolfo Gómez Correa |
| collection | DOAJ |
| description | Case Description. A 72-year-old woman with primary Sjögren Syndrome (SS) was diagnosed during an inpatient hospital stay with dry symptoms. The patient had respiratory and constitutional symptoms, requiring a pulmonary imaging evaluation by high-resolution computed tomography (HRCT) of the thorax. Clinical Findings. Multiple cavitary pulmonary nodules, halo sign, and focal areas of ground-glass opacity with predominance in both bases were found in the images. Complementary studies were done where a neoplastic focus was ruled out. The diagnosis of nodular pulmonary amyloidosis was confirmed with a pulmonary biopsy performed by videothoracoscopy for histopathological study, which reported the formation of nodules in the parenchyma with amyloid deposits and positive immunohistochemical markers for CD3, CD20, and CD38 lymphocytic infiltration. Treatment and Outcome. Initial inpatient management with intravenous cyclophosphamide and methylprednisolone was given. Subsequent outpatient management was given with high dose glucocorticoids. Clinical Relevance. We presented a case of nodular pulmonary amyloidosis in a female patient with primary SS, which is a rare pulmonary manifestation of this syndrome. |
| format | Article |
| id | doaj-art-6583a799ebfd424bb836abdcc74f678b |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-6583a799ebfd424bb836abdcc74f678b2025-08-20T03:34:17ZengWileyCase Reports in Pulmonology2090-68462090-68542018-01-01201810.1155/2018/97459359745935Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s SyndromeGustavo Adolfo Gómez Correa0Jovani Osorno Serna1Manuel Felipe Cáceres Acosta2Juan David Cáceres González3Jaime Andrés Calle Ramirez4Juan Paulo Sandoval Mesa5Miguel Ignacio Roldán Pérez6Specialist in Internal Medicine and Pneumology, Department of Internal Medicine, Universidad de Antioquia, San Vicente Foundation University Hospital, ColombiaSpecialist in Internal Medicine, Pneumology, Thoracic Oncology and Epidemiology, Department of Internal Medicine, Universidad de Antioquia, San Vicente Foundation University Hospital, ColombiaResident of Internal Medicine, Universidad del Cauca, ColombiaUndergraduate Medical Student, Universidad de Antioquia, ColombiaResident of Internal Medicine, Universidad de Antioquia, ColombiaResident of Pathology, Universidad de Antioquia, ColombiaSpecialist in Pathology, Department of Pathology, Universidad de Antioquia, San Vicente Foundation University Hospital, ColombiaCase Description. A 72-year-old woman with primary Sjögren Syndrome (SS) was diagnosed during an inpatient hospital stay with dry symptoms. The patient had respiratory and constitutional symptoms, requiring a pulmonary imaging evaluation by high-resolution computed tomography (HRCT) of the thorax. Clinical Findings. Multiple cavitary pulmonary nodules, halo sign, and focal areas of ground-glass opacity with predominance in both bases were found in the images. Complementary studies were done where a neoplastic focus was ruled out. The diagnosis of nodular pulmonary amyloidosis was confirmed with a pulmonary biopsy performed by videothoracoscopy for histopathological study, which reported the formation of nodules in the parenchyma with amyloid deposits and positive immunohistochemical markers for CD3, CD20, and CD38 lymphocytic infiltration. Treatment and Outcome. Initial inpatient management with intravenous cyclophosphamide and methylprednisolone was given. Subsequent outpatient management was given with high dose glucocorticoids. Clinical Relevance. We presented a case of nodular pulmonary amyloidosis in a female patient with primary SS, which is a rare pulmonary manifestation of this syndrome.http://dx.doi.org/10.1155/2018/9745935 |
| spellingShingle | Gustavo Adolfo Gómez Correa Jovani Osorno Serna Manuel Felipe Cáceres Acosta Juan David Cáceres González Jaime Andrés Calle Ramirez Juan Paulo Sandoval Mesa Miguel Ignacio Roldán Pérez Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome Case Reports in Pulmonology |
| title | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome |
| title_full | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome |
| title_fullStr | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome |
| title_full_unstemmed | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome |
| title_short | Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome |
| title_sort | nodular pulmonary amyloidosis a manifestation of sjogren s syndrome |
| url | http://dx.doi.org/10.1155/2018/9745935 |
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