Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease
Evaluation of motor symptoms in Parkinson’s disease (PD) is still based on clinical rating scales by clinicians. Reaction time (RT) is the time interval between a specific stimulus and the start of muscle response. The aim of this study was to identify the characteristics of RT responses in PD patie...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2014/848035 |
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| author | Do-Young Kwon Byung Kyu Park Ji Won Kim Gwang-Moon Eom Junghwa Hong Seong-Beom Koh Kun-Woo Park |
| author_facet | Do-Young Kwon Byung Kyu Park Ji Won Kim Gwang-Moon Eom Junghwa Hong Seong-Beom Koh Kun-Woo Park |
| author_sort | Do-Young Kwon |
| collection | DOAJ |
| description | Evaluation of motor symptoms in Parkinson’s disease (PD) is still based on clinical rating scales by clinicians. Reaction time (RT) is the time interval between a specific stimulus and the start of muscle response. The aim of this study was to identify the characteristics of RT responses in PD patients using electromyography (EMG) and to elucidate the relationship between RT and clinical features of PD. The EMG activity of 31 PD patients was recorded during isometric muscle contraction. RT was defined as the time latency between an auditory beep and responsive EMG activity. PD patients demonstrated significant delays in both initiation and termination of muscle contraction compared with controls. Cardinal motor symptoms of PD were closely correlated with RT. RT was longer in more-affected side and in more-advanced PD stages. Frontal cognitive function, which is indicative of motor programming and movement regulation and perseveration, was also closely related with RT. In conclusion, greater RT is the characteristic motor features of PD and it could be used as a sensitive tool for motor function assessment in PD patients. Further investigations are required to clarify the clinical impact of the RT on the activity of daily living of patients with PD. |
| format | Article |
| id | doaj-art-65826eddee5341e2ae7d1c4a63adac84 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-65826eddee5341e2ae7d1c4a63adac842025-02-03T06:12:32ZengWileyParkinson's Disease2090-80832042-00802014-01-01201410.1155/2014/848035848035Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s DiseaseDo-Young Kwon0Byung Kyu Park1Ji Won Kim2Gwang-Moon Eom3Junghwa Hong4Seong-Beom Koh5Kun-Woo Park6Department of Neurology, Korea University College of Medicine, Ansan Hospital, 516 Gojan-1-dong, Danwon-gu, Ansan-city, Gyeonggi-do 425-707, Republic of KoreaDepartment of Physical Medicine & Rehabilitation, Korea University College of Medicine, Ansan Hospital, 516 Gojan-1-dong, Danwon-gu, Ansan-city, Gyeonggi-do 425-707, Republic of KoreaSchool of Biomedical Engineering, Konkuk University, Seoul, Republic of KoreaSchool of Biomedical Engineering, Konkuk University, Seoul, Republic of KoreaDepartment of Control and Instrumentation Engineering, Korea University, Seoul, Republic of KoreaDepartment of Neurology, Korea University College of Medicine, Ansan Hospital, 516 Gojan-1-dong, Danwon-gu, Ansan-city, Gyeonggi-do 425-707, Republic of KoreaDepartment of Neurology, Korea University College of Medicine, Ansan Hospital, 516 Gojan-1-dong, Danwon-gu, Ansan-city, Gyeonggi-do 425-707, Republic of KoreaEvaluation of motor symptoms in Parkinson’s disease (PD) is still based on clinical rating scales by clinicians. Reaction time (RT) is the time interval between a specific stimulus and the start of muscle response. The aim of this study was to identify the characteristics of RT responses in PD patients using electromyography (EMG) and to elucidate the relationship between RT and clinical features of PD. The EMG activity of 31 PD patients was recorded during isometric muscle contraction. RT was defined as the time latency between an auditory beep and responsive EMG activity. PD patients demonstrated significant delays in both initiation and termination of muscle contraction compared with controls. Cardinal motor symptoms of PD were closely correlated with RT. RT was longer in more-affected side and in more-advanced PD stages. Frontal cognitive function, which is indicative of motor programming and movement regulation and perseveration, was also closely related with RT. In conclusion, greater RT is the characteristic motor features of PD and it could be used as a sensitive tool for motor function assessment in PD patients. Further investigations are required to clarify the clinical impact of the RT on the activity of daily living of patients with PD.http://dx.doi.org/10.1155/2014/848035 |
| spellingShingle | Do-Young Kwon Byung Kyu Park Ji Won Kim Gwang-Moon Eom Junghwa Hong Seong-Beom Koh Kun-Woo Park Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease Parkinson's Disease |
| title | Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease |
| title_full | Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease |
| title_fullStr | Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease |
| title_full_unstemmed | Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease |
| title_short | Quantitative Electromyographic Analysis of Reaction Time to External Auditory Stimuli in Drug-Naïve Parkinson’s Disease |
| title_sort | quantitative electromyographic analysis of reaction time to external auditory stimuli in drug naive parkinson s disease |
| url | http://dx.doi.org/10.1155/2014/848035 |
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