Cerium Oxide Nanoparticles Achieve Long‐Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation

Cerium Oxide Nanoparticles Achieve Long‐Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation

Most drugs used to treat sarcopenia are ineffective. Herein, the long‐acting anti‐sarcopenic properties of cerium oxide nanoparticles (CeNPs) and their underlying mechanisms of action are investigated in aging mice (treated with 4‐hydroperoxy cyclophosphamide (4‐HC)). CeNPs (size, 27.5 nm) with a fl...

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Bibliographic Details
Main Authors: Wei‐Chih Lien, Yu‐Ling Yu, Ya‐Jyun Liang, Chia‐Yih Wang, Yang‐Chen Lin, Huei‐Cih Chang, Feng‐Huei Lin, Hui‐Min David Wang
Format: Article
Language:English
Published: Wiley-VCH 2025-08-01
Series:Small Science
Subjects:
aging
cartilage intermediate layer protein 2
cellular senescence
cerium oxide nanoparticles
reactive oxygen species
sarcopenia
Online Access:https://doi.org/10.1002/smsc.202500208
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