Advances in research regarding epithelial-mesenchymal transition and prostate cancer
Prostate cancer (PCa) is the most prevalent cancer in men and the fifth leading cause of cancer-related mortality among men globally. Despite substantial advancements in patient prognosis attributable to improvements in PCa treatment, individuals with metastatic castration-resistant prostate cancer...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1583255/full |
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| _version_ | 1849689727276417024 |
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| author | Xi Wei Rui Liu Wei Li Qi Yu Qing Tao Yang Tao Li |
| author_facet | Xi Wei Rui Liu Wei Li Qi Yu Qing Tao Yang Tao Li |
| author_sort | Xi Wei |
| collection | DOAJ |
| description | Prostate cancer (PCa) is the most prevalent cancer in men and the fifth leading cause of cancer-related mortality among men globally. Despite substantial advancements in patient prognosis attributable to improvements in PCa treatment, individuals with metastatic castration-resistant prostate cancer continue to experience poor outcomes. Epithelial-mesenchymal transition (EMT) is characterized as a cellular event in which epithelial cells adopt a mesenchymal phenotype while simultaneously losing their epithelial characteristics. EMT has been demonstrated to be associated with the progression of PCa, encompassing tumor metastasis, recurrence, drug resistance, and the development of an immunosuppressive microenvironment. Consequently, this review synthesizes recent studies on EMT in PCa, consolidating the events mediated by EMT in the progression of PCa and the molecular mechanisms linked to EMT activation in this context. |
| format | Article |
| id | doaj-art-657cb10503fc408c9fceb36c00ded04b |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-657cb10503fc408c9fceb36c00ded04b2025-08-20T03:21:31ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-05-011310.3389/fcell.2025.15832551583255Advances in research regarding epithelial-mesenchymal transition and prostate cancerXi WeiRui LiuWei LiQi YuQing Tao YangTao LiProstate cancer (PCa) is the most prevalent cancer in men and the fifth leading cause of cancer-related mortality among men globally. Despite substantial advancements in patient prognosis attributable to improvements in PCa treatment, individuals with metastatic castration-resistant prostate cancer continue to experience poor outcomes. Epithelial-mesenchymal transition (EMT) is characterized as a cellular event in which epithelial cells adopt a mesenchymal phenotype while simultaneously losing their epithelial characteristics. EMT has been demonstrated to be associated with the progression of PCa, encompassing tumor metastasis, recurrence, drug resistance, and the development of an immunosuppressive microenvironment. Consequently, this review synthesizes recent studies on EMT in PCa, consolidating the events mediated by EMT in the progression of PCa and the molecular mechanisms linked to EMT activation in this context.https://www.frontiersin.org/articles/10.3389/fcell.2025.1583255/fullprostate cancerepithelial-mesenchymal transitiontumor progressiontumor drug resistanceheterogeneity |
| spellingShingle | Xi Wei Rui Liu Wei Li Qi Yu Qing Tao Yang Tao Li Advances in research regarding epithelial-mesenchymal transition and prostate cancer Frontiers in Cell and Developmental Biology prostate cancer epithelial-mesenchymal transition tumor progression tumor drug resistance heterogeneity |
| title | Advances in research regarding epithelial-mesenchymal transition and prostate cancer |
| title_full | Advances in research regarding epithelial-mesenchymal transition and prostate cancer |
| title_fullStr | Advances in research regarding epithelial-mesenchymal transition and prostate cancer |
| title_full_unstemmed | Advances in research regarding epithelial-mesenchymal transition and prostate cancer |
| title_short | Advances in research regarding epithelial-mesenchymal transition and prostate cancer |
| title_sort | advances in research regarding epithelial mesenchymal transition and prostate cancer |
| topic | prostate cancer epithelial-mesenchymal transition tumor progression tumor drug resistance heterogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1583255/full |
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