Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation

Abstract Cancer cell populations, such as chronic lymphocytic leukemia (CLL), are characterized by aberrant proliferation and plasticity: cells may switch between states so increasing population heterogeneity. Previous works have shown that gene expression noise can impact cell-state transition. To...

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Bibliographic Details
Main Authors: Olga Sirbu, Gunjan Agarwal, Alessandro Giuliani, Kumar Selvarajoo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00575-1
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