Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation
Abstract Cancer cell populations, such as chronic lymphocytic leukemia (CLL), are characterized by aberrant proliferation and plasticity: cells may switch between states so increasing population heterogeneity. Previous works have shown that gene expression noise can impact cell-state transition. To...
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| Main Authors: | Olga Sirbu, Gunjan Agarwal, Alessandro Giuliani, Kumar Selvarajoo |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-025-00575-1 |
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