A global living systematic review and meta-analysis hub of emerging vaccines in pregnancy and childhood

Abstract The COVID-19 pandemic accelerated vaccine development and generated a rapidly evolving body of evidence before and after the vaccine rollout. We developed a robust online platform to efficiently synthesize this emerging information for current and future challenges. Expanding upon our inter...

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Main Authors: Agustín Ciapponi, Ariel Bardach, Mabel Berrueta, Jamile Ballivian, Martin Brizuela, Julieta Caravario, Noelia Castellana, Daniel Comande, Esteban Couto, Agustina Mazzoni, Vanesa Ortega, Edward P. K. Parker, Juan M. Sambade, Salva Florencia, Juan Pablo Smutny, Katharina Stegelmann, Xu Xiong, Andy Stergachis, Flor M. Munoz, Pierre Buekens
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Reproductive Health
Online Access:https://doi.org/10.1186/s12978-025-02090-2
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Summary:Abstract The COVID-19 pandemic accelerated vaccine development and generated a rapidly evolving body of evidence before and after the vaccine rollout. We developed a robust online platform to efficiently synthesize this emerging information for current and future challenges. Expanding upon our interactive living systematic review—initially focused on COVID-19— we now include chikungunya and Lassa fever (with protocols presented in this issue), Mpox, and Disease X ( https://www.safeinpregnancy.org ). We aim to continuously monitor and periodically update and disseminate high-quality data on vaccine safety, efficacy, effectiveness, and immunogenicity in pregnancy and childhood. This platform computes real-time meta-analyses and features a visualization tool to present findings in a clear and accessible manner, supporting decision-making, vaccine development pipelines, and implementation strategies worldwide. It is also designed to integrate data on a hub of emerging vaccines in pregnancy and childhood and reflects a collaborative effort among multiple organizations.
ISSN:1742-4755