Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from Pakistan
OBJECTIVE: To determine the structural abnormalities on magnetic resonance imaging (MRI) in the epileptic Pakistani pediatric population presenting at Tertiary Care Hospital, Karachi. METHODS: This cross-sectional descriptive study was done at the CT & MRI Center, Dr Ruth K.M Pfau Civil Hospit...
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Khyber Medical University
2024-06-01
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| Series: | Khyber Medical University Journal |
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| Online Access: | https://www.kmuj.kmu.edu.pk/article/view/23363 |
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| author | Rehana Shaikh Saba Sohail Sabiha Zaheer |
| author_facet | Rehana Shaikh Saba Sohail Sabiha Zaheer |
| author_sort | Rehana Shaikh |
| collection | DOAJ |
| description | OBJECTIVE: To determine the structural abnormalities on magnetic resonance imaging (MRI) in the epileptic Pakistani pediatric population presenting at Tertiary Care Hospital, Karachi.
METHODS: This cross-sectional descriptive study was done at the CT & MRI Center, Dr Ruth K.M Pfau Civil Hospital Karachi, from February 2019 to January 2020. This study enrolled 173 subjects of either gender between 1-14 years of age with epilepsy who underwent an MRI of the brain. An MRI brain with epilepsy protocol was performed after taking a history from each patient. Abnormalities were reported according to their imaging features, signal intensity, and location.
RESULTS: Of the 173 subjects, 94 (54.3%) were boys and 79 (45.7%) were girls, with mean age of 6.7±3.3 years. Generalized seizures were predominant (n=103; 59.5%), followed by focal seizures (n=57; 33%), and unknown seizure patterns (n=13; 7.5%). MRI findings were unremarkable in 68 (39.3%) cases, predominantly in both generalized (35.84%) and focal (2.31%) epilepsy cases. Structural abnormalities were evident in 105 (60.7%) patients on MRI. Cerebral atrophy was predominant (11.56%), especially in generalized epilepsy cases. Encephalomalacia (6.94%) and ventricular enlargement (6.36%) were observed, with encephalomalacia more prevalent in focal epilepsy and ventricular enlargement in generalized epilepsy. Mesial temporal sclerosis (5.7%) was significant in focal epilepsy cases. The highest prevalence of unremarkable MRI findings was in the 6-10 years’ age group (20.2%).
CONCLUSION: MRI detected abnormalities in 60.7% cases of paediatric epilepsy, most commonly cerebral atrophy and encephalomalacia, emphasizing MRI's role in assessing epilepsy-related structural changes and the need for targeted interventions. |
| format | Article |
| id | doaj-art-65777aa376264d488f2adc432d20f739 |
| institution | OA Journals |
| issn | 2305-2643 2305-2651 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Khyber Medical University |
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| series | Khyber Medical University Journal |
| spelling | doaj-art-65777aa376264d488f2adc432d20f7392025-08-20T01:47:23ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512024-06-011621293310.35845/kmuj.2024.233632135Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from PakistanRehana Shaikh0Saba Sohail1Sabiha Zaheer2Radiology Department, Dow University of Health Sciences/ Dr Ruth K.M. Pfau Civil Hospital Karachi, Pakistan Radiology Department, Dow University of Health Sciences/ Dr Ruth K.M. Pfau Civil Hospital Karachi, Pakistan Radiology Department, Sindh Govt. Hospital Ibrahim Hyderi, Karachi, PakistanOBJECTIVE: To determine the structural abnormalities on magnetic resonance imaging (MRI) in the epileptic Pakistani pediatric population presenting at Tertiary Care Hospital, Karachi. METHODS: This cross-sectional descriptive study was done at the CT & MRI Center, Dr Ruth K.M Pfau Civil Hospital Karachi, from February 2019 to January 2020. This study enrolled 173 subjects of either gender between 1-14 years of age with epilepsy who underwent an MRI of the brain. An MRI brain with epilepsy protocol was performed after taking a history from each patient. Abnormalities were reported according to their imaging features, signal intensity, and location. RESULTS: Of the 173 subjects, 94 (54.3%) were boys and 79 (45.7%) were girls, with mean age of 6.7±3.3 years. Generalized seizures were predominant (n=103; 59.5%), followed by focal seizures (n=57; 33%), and unknown seizure patterns (n=13; 7.5%). MRI findings were unremarkable in 68 (39.3%) cases, predominantly in both generalized (35.84%) and focal (2.31%) epilepsy cases. Structural abnormalities were evident in 105 (60.7%) patients on MRI. Cerebral atrophy was predominant (11.56%), especially in generalized epilepsy cases. Encephalomalacia (6.94%) and ventricular enlargement (6.36%) were observed, with encephalomalacia more prevalent in focal epilepsy and ventricular enlargement in generalized epilepsy. Mesial temporal sclerosis (5.7%) was significant in focal epilepsy cases. The highest prevalence of unremarkable MRI findings was in the 6-10 years’ age group (20.2%). CONCLUSION: MRI detected abnormalities in 60.7% cases of paediatric epilepsy, most commonly cerebral atrophy and encephalomalacia, emphasizing MRI's role in assessing epilepsy-related structural changes and the need for targeted interventions.https://www.kmuj.kmu.edu.pk/article/view/23363epilepsy magnetic resonance imagingmripediatrics nervous system malformationsstructural abnormalitiescerebral atrophydiagnostic imaging |
| spellingShingle | Rehana Shaikh Saba Sohail Sabiha Zaheer Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from Pakistan Khyber Medical University Journal epilepsy magnetic resonance imaging mri pediatrics nervous system malformations structural abnormalities cerebral atrophy diagnostic imaging |
| title | Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from Pakistan |
| title_full | Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from Pakistan |
| title_fullStr | Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from Pakistan |
| title_full_unstemmed | Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from Pakistan |
| title_short | Magnetic Resonance Imaging findings in pediatric patients with Epilepsy: a single-center experience from Pakistan |
| title_sort | magnetic resonance imaging findings in pediatric patients with epilepsy a single center experience from pakistan |
| topic | epilepsy magnetic resonance imaging mri pediatrics nervous system malformations structural abnormalities cerebral atrophy diagnostic imaging |
| url | https://www.kmuj.kmu.edu.pk/article/view/23363 |
| work_keys_str_mv | AT rehanashaikh magneticresonanceimagingfindingsinpediatricpatientswithepilepsyasinglecenterexperiencefrompakistan AT sabasohail magneticresonanceimagingfindingsinpediatricpatientswithepilepsyasinglecenterexperiencefrompakistan AT sabihazaheer magneticresonanceimagingfindingsinpediatricpatientswithepilepsyasinglecenterexperiencefrompakistan |