Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment
Purpose: To evaluate optic disc and macular microvasculature changes in children with anisometropic amblyopia before and after treatment. Methods: In all, 60 children with unilateral anisometropic amblyopia between the ages of 6 and 12 were randomly selected from the ophthalmology clinic of Fuyang P...
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Elsevier
2025-04-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000110 |
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| author | Jia-Hao Li Chen-Yu Yang Jia-Yu Ma Jing Wang Ying-Jun Li |
| author_facet | Jia-Hao Li Chen-Yu Yang Jia-Yu Ma Jing Wang Ying-Jun Li |
| author_sort | Jia-Hao Li |
| collection | DOAJ |
| description | Purpose: To evaluate optic disc and macular microvasculature changes in children with anisometropic amblyopia before and after treatment. Methods: In all, 60 children with unilateral anisometropic amblyopia between the ages of 6 and 12 were randomly selected from the ophthalmology clinic of Fuyang People's Hospital, while 60 children with non-amblyopia in the same age range were randomly selected as a normal control group. The right eye was uniformly taken in the control group with at least 6 months of follow-up. Optical coherence tomography angiography (OCTA) was used to evaluate the macular vessel density of superficial capillary plexus (SCP) and deep capillary plexus (DCP), optic disc vascular density (VD), foveal avascular zone (FAZ) area, macular thickness, and retinal nerve fiber layer thickness (RNFLT). Results: Before treatment, the vessel density of the optic disc, macular SCP and DCP in the amblyopic group was significantly lower than those in the fellow eyes and the control group (P < 0.05), while there were no statistically significant differences in the vessel densities of the optic disc, macular SCP and DCP between the amblyopic eyes, the fellow eyes, and the control group after treatment (P > 0.05). Statistically significant negative correlations were found between the alterations of BCVA in amblyopic eyes and the alterations of the vessel densities of the optic disc, macular SCP and DCP in amblyopia eyes (P < 0.05) except for superior nasal (SN) and inferior nasal (IN) regions of the optic disc radial peripapillary capillary, temporal and nasal regions of macular parafoveal SCP, nasal regions of macular parafoveal DCP and inferior regions of macular perifoveal DCP (P > 0.05). Conclusion: Macular and optic disc vessel density in OCTA are lower in children with anisometropic amblyopia and tend to return to normal levels to a certain extent following treatment for amblyopia. |
| format | Article |
| id | doaj-art-65766e291358469f972de2310a57d231 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-65766e291358469f972de2310a57d2312025-02-05T04:31:18ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-04-0152104481Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatmentJia-Hao Li0Chen-Yu Yang1Jia-Yu Ma2Jing Wang3Ying-Jun Li4Department of Ophthalmology, Fuyang Hospital Affiliated to Bengbu Medical University(Fuyang People's Hospital), Fuyang, 236400, Anhui Province, ChinaDepartment of Ophthalmology, Fuyang Hospital Affiliated to Bengbu Medical University(Fuyang People's Hospital), Fuyang, 236400, Anhui Province, ChinaDepartment of Ophthalmology, Fuyang People's Hospital of Anhui Medical University, Fuyang, 236400, Anhui Province, ChinaDepartment of Ophthalmology, Fuyang Hospital Affiliated to Bengbu Medical University(Fuyang People's Hospital), Fuyang, 236400, Anhui Province, ChinaDepartment of Ophthalmology, Fuyang Hospital Affiliated to Bengbu Medical University(Fuyang People's Hospital), Fuyang, 236400, Anhui Province, China; Corresponding author.Purpose: To evaluate optic disc and macular microvasculature changes in children with anisometropic amblyopia before and after treatment. Methods: In all, 60 children with unilateral anisometropic amblyopia between the ages of 6 and 12 were randomly selected from the ophthalmology clinic of Fuyang People's Hospital, while 60 children with non-amblyopia in the same age range were randomly selected as a normal control group. The right eye was uniformly taken in the control group with at least 6 months of follow-up. Optical coherence tomography angiography (OCTA) was used to evaluate the macular vessel density of superficial capillary plexus (SCP) and deep capillary plexus (DCP), optic disc vascular density (VD), foveal avascular zone (FAZ) area, macular thickness, and retinal nerve fiber layer thickness (RNFLT). Results: Before treatment, the vessel density of the optic disc, macular SCP and DCP in the amblyopic group was significantly lower than those in the fellow eyes and the control group (P < 0.05), while there were no statistically significant differences in the vessel densities of the optic disc, macular SCP and DCP between the amblyopic eyes, the fellow eyes, and the control group after treatment (P > 0.05). Statistically significant negative correlations were found between the alterations of BCVA in amblyopic eyes and the alterations of the vessel densities of the optic disc, macular SCP and DCP in amblyopia eyes (P < 0.05) except for superior nasal (SN) and inferior nasal (IN) regions of the optic disc radial peripapillary capillary, temporal and nasal regions of macular parafoveal SCP, nasal regions of macular parafoveal DCP and inferior regions of macular perifoveal DCP (P > 0.05). Conclusion: Macular and optic disc vessel density in OCTA are lower in children with anisometropic amblyopia and tend to return to normal levels to a certain extent following treatment for amblyopia.http://www.sciencedirect.com/science/article/pii/S1572100025000110Anisometropic amblyopiaOptical coherence tomography angiographyOptic disc microvasculatureMacular microvasculature |
| spellingShingle | Jia-Hao Li Chen-Yu Yang Jia-Yu Ma Jing Wang Ying-Jun Li Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment Photodiagnosis and Photodynamic Therapy Anisometropic amblyopia Optical coherence tomography angiography Optic disc microvasculature Macular microvasculature |
| title | Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment |
| title_full | Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment |
| title_fullStr | Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment |
| title_full_unstemmed | Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment |
| title_short | Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment |
| title_sort | comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment |
| topic | Anisometropic amblyopia Optical coherence tomography angiography Optic disc microvasculature Macular microvasculature |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000110 |
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