Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry
Background: In atopic dermatitis (AD), the real-world impact of achieving itch and skin lesion treatment targets compared to partial improvement remains unclear.Objective: We assessed the relationship between itch relief (reduction in Worst Itch Numeric Rating Scale [WI-NRS]) and skin clearance (Inv...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2024.2428729 |
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| author | Jonathan I. Silverberg Brian M. Calimlim Ayman Grada Christopher G. Bunick Melinda J. Gooderham Vivian Y. Shi Chibuzo Obi Keith D. Knapp Breda Munoz Julie M. Crawford Amy S. Paller |
| author_facet | Jonathan I. Silverberg Brian M. Calimlim Ayman Grada Christopher G. Bunick Melinda J. Gooderham Vivian Y. Shi Chibuzo Obi Keith D. Knapp Breda Munoz Julie M. Crawford Amy S. Paller |
| author_sort | Jonathan I. Silverberg |
| collection | DOAJ |
| description | Background: In atopic dermatitis (AD), the real-world impact of achieving itch and skin lesion treatment targets compared to partial improvement remains unclear.Objective: We assessed the relationship between itch relief (reduction in Worst Itch Numeric Rating Scale [WI-NRS]) and skin clearance (Investigator Global Assessment [IGA] 0/1) with other patient-reported outcomes.Methods: Using TARGET-DERM AD registry data on adults receiving standard-of-care treatment, we described and modeled the relationship of itch severity (Worst Itch Numeric Rating Scale [WI-NRS]) and skin lesion severity (IGA) outcomes with patient-reported (quality of life ([DLQI)], AD severity [(POEM]), sleep ([Sleep-NRS]), and skin pain [(Pain-NRS]).Results: Among 1,920 participants (58.6% female; 54.5% Non-Hispanic White; 93.8% US; mean age 45 years), ideal outcomes (DLQI 0/1, POEM 0-2, Sleep-NRS 0/1, and Pain-NRS 0/1) were most frequent for those achieving the optimal targets for itch (WI-NRS 0/1; 52.1%, 53.7%, 57.3%, and 83.1%, respectively) and skin clearance (IGA 0/1; 44.7%, 44.3%, 44.7%, and 74.3%, respectively). The odds ratios of ideal outcomes were greatest for participants with complete or near-complete resolution of both itch and skin (DLQI 0/120.0; POEM 0-2: 41.7; Sleep-NRS: 16.1; Pain-NRS: 6.0).Conclusions: Achieving optimal treatment targets for both itch and skin lesion improvement markedly enhances patient-reported AD outcomes. The results of this study support using minimal disease activity criteria to assess therapeutic effectiveness. |
| format | Article |
| id | doaj-art-656d3fbe0e1f44efb8e3dbd07c85b055 |
| institution | DOAJ |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-656d3fbe0e1f44efb8e3dbd07c85b0552025-08-20T02:49:32ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532024-12-0135110.1080/09546634.2024.2428729Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registryJonathan I. Silverberg0Brian M. Calimlim1Ayman Grada2Christopher G. Bunick3Melinda J. Gooderham4Vivian Y. Shi5Chibuzo Obi6Keith D. Knapp7Breda Munoz8Julie M. Crawford9Amy S. Paller10George Washington University School of Medicine and Health Sciences, Washington D.C, USAAbbVie Inc, North Chicago, IL, USAAbbVie Inc, North Chicago, IL, USADepartment of Dermatology and Program in Translational Biomedicine, Yale University School of Medicine New Haven, CT, USASKiN Centre for Dermatology, Peterborough, Ontario, CanadaDepartment of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, USAAbbVie Inc, North Chicago, IL, USATarget RWE, Durham, NC, USATarget RWE, Durham, NC, USATarget RWE, Durham, NC, USADepartments of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USABackground: In atopic dermatitis (AD), the real-world impact of achieving itch and skin lesion treatment targets compared to partial improvement remains unclear.Objective: We assessed the relationship between itch relief (reduction in Worst Itch Numeric Rating Scale [WI-NRS]) and skin clearance (Investigator Global Assessment [IGA] 0/1) with other patient-reported outcomes.Methods: Using TARGET-DERM AD registry data on adults receiving standard-of-care treatment, we described and modeled the relationship of itch severity (Worst Itch Numeric Rating Scale [WI-NRS]) and skin lesion severity (IGA) outcomes with patient-reported (quality of life ([DLQI)], AD severity [(POEM]), sleep ([Sleep-NRS]), and skin pain [(Pain-NRS]).Results: Among 1,920 participants (58.6% female; 54.5% Non-Hispanic White; 93.8% US; mean age 45 years), ideal outcomes (DLQI 0/1, POEM 0-2, Sleep-NRS 0/1, and Pain-NRS 0/1) were most frequent for those achieving the optimal targets for itch (WI-NRS 0/1; 52.1%, 53.7%, 57.3%, and 83.1%, respectively) and skin clearance (IGA 0/1; 44.7%, 44.3%, 44.7%, and 74.3%, respectively). The odds ratios of ideal outcomes were greatest for participants with complete or near-complete resolution of both itch and skin (DLQI 0/120.0; POEM 0-2: 41.7; Sleep-NRS: 16.1; Pain-NRS: 6.0).Conclusions: Achieving optimal treatment targets for both itch and skin lesion improvement markedly enhances patient-reported AD outcomes. The results of this study support using minimal disease activity criteria to assess therapeutic effectiveness.https://www.tandfonline.com/doi/10.1080/09546634.2024.2428729Atopic dermatitispainitchskin clearancequality-of-lifeeczema |
| spellingShingle | Jonathan I. Silverberg Brian M. Calimlim Ayman Grada Christopher G. Bunick Melinda J. Gooderham Vivian Y. Shi Chibuzo Obi Keith D. Knapp Breda Munoz Julie M. Crawford Amy S. Paller Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry Journal of Dermatological Treatment Atopic dermatitis pain itch skin clearance quality-of-life eczema |
| title | Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry |
| title_full | Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry |
| title_fullStr | Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry |
| title_full_unstemmed | Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry |
| title_short | Real-world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management: a study from the TARGET-DERM AD registry |
| title_sort | real world evidence on the benefits of optimal itch relief and skin clearance in atopic dermatitis management a study from the target derm ad registry |
| topic | Atopic dermatitis pain itch skin clearance quality-of-life eczema |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2024.2428729 |
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