The Role of Stromal Proteolytic Systems in Cancer Progression (Review)
Oncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available for prevention of critical illness accompanyi...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2019-11-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1821 |
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| author | E. V. Kugaevskaya O. S. Timoshenko T. A. Gureeva N. I. Solovieva |
| author_facet | E. V. Kugaevskaya O. S. Timoshenko T. A. Gureeva N. I. Solovieva |
| author_sort | E. V. Kugaevskaya |
| collection | DOAJ |
| description | Oncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available for prevention of critical illness accompanying this pathological condition.Nowadays, proteolytic systems of tumor microenvironment (ТМЕ) are regarded as key regulators of a tumor progression including tumor growth, invasion and metastazing. The review discusses ТМЕ structure and role in cancer progression.Recent data decipher the role of proteolytic systems in the interaction stromal cells with tumor cells in different types of cancer in humans. The most known proteolytic systems contributed to cancer progression are matrix metalloproteinase system (MMP), urokinase-type plasminogen activator system (uPA-system), various cathepsins, granzymes, and elastase. Inhibition of extracellular proteolysis in the course of an oncological process is considered an effective approach to cancer therapy. |
| format | Article |
| id | doaj-art-656a92b905b649c188ff8625e1f4e07c |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-656a92b905b649c188ff8625e1f4e07c2025-08-20T02:59:35ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102019-11-0115510612610.15360/1813-9779-2019-5-106-1261711The Role of Stromal Proteolytic Systems in Cancer Progression (Review)E. V. Kugaevskaya0O. S. Timoshenko1T. A. Gureeva2N. I. Solovieva3V. N. Orekhovich Research Institute of Biomedical ChemistryV. N. Orekhovich Research Institute of Biomedical ChemistryV. N. Orekhovich Research Institute of Biomedical ChemistryV. N. Orekhovich Research Institute of Biomedical ChemistryOncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available for prevention of critical illness accompanying this pathological condition.Nowadays, proteolytic systems of tumor microenvironment (ТМЕ) are regarded as key regulators of a tumor progression including tumor growth, invasion and metastazing. The review discusses ТМЕ structure and role in cancer progression.Recent data decipher the role of proteolytic systems in the interaction stromal cells with tumor cells in different types of cancer in humans. The most known proteolytic systems contributed to cancer progression are matrix metalloproteinase system (MMP), urokinase-type plasminogen activator system (uPA-system), various cathepsins, granzymes, and elastase. Inhibition of extracellular proteolysis in the course of an oncological process is considered an effective approach to cancer therapy.https://www.reanimatology.com/rmt/article/view/1821carcinogenesis, tumor microenvironment, stroma, matrix metalloproteinases, upa-systemproteolysiscancer progressioninvasionmetastasis |
| spellingShingle | E. V. Kugaevskaya O. S. Timoshenko T. A. Gureeva N. I. Solovieva The Role of Stromal Proteolytic Systems in Cancer Progression (Review) Общая реаниматология carcinogenesis, tumor microenvironment, stroma, matrix metalloproteinases, upa-system proteolysis cancer progression invasion metastasis |
| title | The Role of Stromal Proteolytic Systems in Cancer Progression (Review) |
| title_full | The Role of Stromal Proteolytic Systems in Cancer Progression (Review) |
| title_fullStr | The Role of Stromal Proteolytic Systems in Cancer Progression (Review) |
| title_full_unstemmed | The Role of Stromal Proteolytic Systems in Cancer Progression (Review) |
| title_short | The Role of Stromal Proteolytic Systems in Cancer Progression (Review) |
| title_sort | role of stromal proteolytic systems in cancer progression review |
| topic | carcinogenesis, tumor microenvironment, stroma, matrix metalloproteinases, upa-system proteolysis cancer progression invasion metastasis |
| url | https://www.reanimatology.com/rmt/article/view/1821 |
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