Detection of the 30-bp deletion and protein expression of Epstein-Barr virus latent membrane protein 1 in extranodal NK/T cell lymphoma and its clinicopathological significance

Detection of the 30-bp deletion and protein expression of Epstein-Barr virus latent membrane protein 1 in extranodal NK/T cell lymphoma and its clinicopathological significance

Abstract Background Extranodal natural killer/T-cell lymphoma (ENKTCL) is strongly associated with Epstein-Barr virus (EBV) infection. A 30-base-pair deletion in latent membrane protein 1 (del-LMP1) represents the most common variant in the EBV genome, but its clinicopathological significance in ENK...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xingmei Lu, Qingsong Han, Peng Li, Kate Huang, Xiuhuan Ji, Suidan Chen, Rixu Lin, Xiaoyu Wang
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Series:	Diagnostic Pathology
Subjects:	Extranodal natural killer/T-cell lymphoma (ENKTCL) Latent membrane protein 1 (LMP1) Epstein-Barr virus (EBV)
Online Access:	https://doi.org/10.1186/s13000-025-01607-4
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Epstein-Barr Virus and Classical Hodgkin’s Lymphoma
by: VE Gurtsevich
Published: (2016-04-01)

Molecular and genetic characteristics of Epstein-Barr virus isolates in adult patients with HIV infection in Nizhny Novgorod region
by: Mariia I. Popkova, et al.
Published: (2025-04-01)

EBV Plasma Epstein-Barr Virus (EBV) DNA as a Biomarker for Diagnosis of EBV-positive Hodgkin Lymphoma in Syria
by: Rana Habeeb, et al.
Published: (2021-12-01)

Epstein–Barr virus and mechanisms of molecular carcinogenesis
by: A. D. Molchanov, et al.
Published: (2025-06-01)

Prognostic value of the pre-treatment SUVmax of 18F-FDG PET/CT combined with peripheral absolute lymphocyte in patients with newly diagnosed extranodal natural killer/T-cell lymphoma
by: Xingmei Lu, et al.
Published: (2025-06-01)

T cell-mediated immune surveillance conferred by latent Epstein-Barr virus genes suppresses a broad spectrum of tumor formation through NKG2D-NKG2DL interactions
by: Yuqi Jin, et al.
Published: (2025-06-01)

A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma
by: Deng H, et al.
Published: (2025-01-01)

The clinical and laboratory characteristics of infectious mononucleosis caused by the Epstein-Barr virus type 1 in hospitalized children
by: M. I. Popkova, et al.
Published: (2023-04-01)

The Expression of mRNA LMP1 Epstein-Barr Virus from FFPE Tumour Biopsy: a Potential Biomarker of Nasopharyngeal Carcinoma Diagnosis
by: Daniel Joko Wahyono, et al.
Published: (2017-07-01)

Epstein-Barr Virus in Patients with Classical Hodgkin’s Lymphoma
by: VE Gurtsevitch, et al.
Published: (2018-04-01)

Comparison between ELISA and PCR for Detection of Epstein - Barr virus in children with acute cervical lymphadenitis
by: Nazim Khan, et al.
Published: (2024-11-01)

A yeast model for the mechanism of the Epstein-Barr virus immune evasion identifies a new therapeutic target to interfere with the virus stealthiness
by: KaMaría José Lista, et al.
Published: (2017-08-01)

Epstein-Barr virus-associated autoimmune hemolytic anemia: a clinical report and review of literature
by: Salvatore Accomando, et al.
Published: (2025-04-01)

Anti-Epstein–Barr Virus Activities of Flavones and Flavonols with Effects on Virus-Related Cancers
by: Sherif T. S. Hassan
Published: (2025-02-01)

Epstein-Barr virus type 2 infection is associated with higher viral loads in pediatric tonsils from western Kenya
by: Emmily Koech, et al.
Published: (2025-08-01)

High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study
by: Leyla A. Ovchinnikova, et al.
Published: (2024-11-01)

In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides in patients with multiple sclerosis
by: Nicole Vasilenko, et al.
Published: (2024-12-01)

Diagnostic value of Epstein – Barr virus DNA quantification in blood leukocytes in children with infectious mononucleosis
by: M. I. Popkova, et al.
Published: (2022-07-01)

Clinical features and laboratory findings in children hospitalized with acute Epstein-Barr virus infection: a crosssectional study in a tertiary care hospital
by: İlknur Çağlar, et al.
Published: (2019-06-01)

Epstein-Barr virus mRNA vaccine synergizes with NK cells to enhance nasopharyngeal carcinoma eradication in humanized mice
by: Kun Huang, et al.
Published: (2025-06-01)

Detection of Epstein-Barr virus infection in primary junctional epithelial cell cultures
by: Lilit Tonoyan, et al.
Published: (2024-12-01)

Epstein–Barr Virus and gastric carcinoma pathogenesis with emphasis on underlying epigenetic mechanisms
by: Fatemeh Estaji, et al.
Published: (2024-11-01)

Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host
by: Muhammad Naveed, et al.
Published: (2024-12-01)

Scientific Substantiation of the Creation and Prospects for the Development of an Epidemiological Surveillance System for Infection Caused by the Epstein-Barr Virus
by: T. V. Solomay, et al.
Published: (2022-03-01)

How Epstein Barr Virus Causes Lymphomas
by: Ya-Fang Chiu, et al.
Published: (2024-11-01)

A case of coexistence of hydroa vacciniforme-like lymphoproliferative disorder and Epstein-Barr virus pneumonia
by: Wei Zhang, MD, PhD, et al.
Published: (2025-09-01)

Epstein–Barr virus in the ethnic Tatars population: the infection and sequence variants of LMP1 oncogene
by: K. V. Smirnova, et al.
Published: (2018-11-01)

Primary pulmonary extranodal natural killer/T-cell lymphoma of nasal type presenting as pneumonia in the right lower lobe: A case report
by: Xuefeng Li, et al.
Published: (2024-01-01)

Epstein-Barr Virus and Human Papillomavirus Coinfection in Colorectal Carcinoma: Systematic Review and Meta-Analysis of the Prevalence
by: Ana Banko, et al.
Published: (2024-10-01)

IMMUNOTHERAPY FOR EPSTEIN-BARR VIRUS-RELATED LYMPHOMAS
by: Helen Heslop, et al.
Published: (2009-11-01)

Effects of venetoclax, a BCL2 inhibitor, in systemic chronic active Epstein-Barr virus disease
by: Ayaka Ohashi, et al.
Published: (2025-05-01)

Role of ebv-circRPMS1–p53 interaction in the proliferation and clinical progression of Epstein–Barr virus-associated gastric carcinoma
by: Ling Yang, et al.
Published: (2025-10-01)

Prognostic value of the co-stimulatory molecule OX40 expression in Extranodal Natural Killer/T-cell Lymphoma
by: Haiyan Zhang, et al.
Published: (2025-12-01)

Genetic and clinical distinction between aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma with bone marrow involvement
by: Ju Hyeong Lee, et al.
Published: (2025-07-01)

In Silico Analysis of Dysregulated Genes and Drug Resistance in Epstein-Barr Virus Associated Gastric Cancer
by: Tabassom Sedaghat Anbouhi, et al.
Published: (2023-11-01)

The prognostic value of lactate dehydrogenase/albumin ratio in extranodal natural killer/T cell lymphoma
by: Na Li, et al.
Published: (2025-07-01)

Epstein-Barr Virus (EBV)-associated Haemophagocytic Syndrome
by: Lorenza Torti, et al.
Published: (2012-01-01)

Methylation of drug resistance‐related genes in chemotherapy‐sensitive Epstein–Barr virus‐associated gastric cancer
by: Hirofumi Ohmura, et al.
Published: (2020-01-01)

Prognostic impact of pre-treatment and post-treatment plasma Epstein-Barr virus DNA in peripheral T-cell lymphomas
by: Chu-Yi Chan, et al.
Published: (2025-12-01)

Diabetes, Epstein-Barr virus and extranodal natural killer/T-cell lymphoma in India: Unravelling the plausible nexus
by: Anita Spadigam, et al.
Published: (2016-01-01)