Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation
Background/Aim. New and improved definition of dry eye disease (DED) emphasized that hiperosmolarity and inflammation with initial tear film instability play etiological role. The aim of this study was to explore relation of some commonly used clinical tests to dry eye disease (DED) related inflamma...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2019-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501700185D.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850253131930140672 |
|---|---|
| author | Dačić-Krnjaja Bojana Potić Jelena Raonić Danijela Stojković Milenko |
| author_facet | Dačić-Krnjaja Bojana Potić Jelena Raonić Danijela Stojković Milenko |
| author_sort | Dačić-Krnjaja Bojana |
| collection | DOAJ |
| description | Background/Aim. New and improved definition of dry eye disease (DED) emphasized that hiperosmolarity and inflammation with initial tear film instability play etiological role. The aim of this study was to explore relation of some commonly used clinical tests to dry eye disease (DED) related inflammation measured by conjunctival scraping cytology. Methods. We examined 100 subjects, 80 of them having DED. We performed Schirmer without anesthesia (Schirmer I), Fluorescein Tear Break Up Time (FTBUT), Rose Bengal (RB), Lid Parallel Conjunctival Folds (LIPCOF), Tear Meniscus Height (TMH) and Tear Ferning (TF) and compared the values to scraping scores of tarsal conjunctiva. Results. FTBUT had the best sensitivity (93.6%). The highest specificity was found with RB (93.2%), but it was also high with Schirmer I, TF and FTBUT (respectively 89.8%, 84.5%, 78.0%). RB and FTBUT had the highest correlation with conjunctival scraping score (r = 0.707, p < 0.001; r = -0.507, p < 0.001). Conclusion. In our study, FTBUT, though often used in many combinations of the DED tests, showed a remarkably high sensitivity and specificity on its own, as well as good correlation with DED related inflammation detected with conjunctival scraping cytology. |
| format | Article |
| id | doaj-art-65626f5022044bdaa8ee4bc178a70501 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-65626f5022044bdaa8ee4bc178a705012025-08-20T01:57:27ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202019-01-0176987587910.2298/VSP171109185D0042-84501700185DCorrelation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammationDačić-Krnjaja Bojana0Potić Jelena1Raonić Danijela2Stojković Milenko3University of Belgrade, Faculty of Medicine, Belgrade, Serbia + Clinical Center of Serbia, Clinic for Eye Diseases, Belgrade, SerbiaClinical Center of Serbia, Clinic for Eye Diseases, Belgrade, SerbiaClinical Centre of Montenegro, Clinic for Eye Disease, Podgorica, MontenegroUniversity of Belgrade, Faculty of Medicine, Belgrade, Serbia + Clinical Center of Serbia, Clinic for Eye Diseases, Belgrade, SerbiaBackground/Aim. New and improved definition of dry eye disease (DED) emphasized that hiperosmolarity and inflammation with initial tear film instability play etiological role. The aim of this study was to explore relation of some commonly used clinical tests to dry eye disease (DED) related inflammation measured by conjunctival scraping cytology. Methods. We examined 100 subjects, 80 of them having DED. We performed Schirmer without anesthesia (Schirmer I), Fluorescein Tear Break Up Time (FTBUT), Rose Bengal (RB), Lid Parallel Conjunctival Folds (LIPCOF), Tear Meniscus Height (TMH) and Tear Ferning (TF) and compared the values to scraping scores of tarsal conjunctiva. Results. FTBUT had the best sensitivity (93.6%). The highest specificity was found with RB (93.2%), but it was also high with Schirmer I, TF and FTBUT (respectively 89.8%, 84.5%, 78.0%). RB and FTBUT had the highest correlation with conjunctival scraping score (r = 0.707, p < 0.001; r = -0.507, p < 0.001). Conclusion. In our study, FTBUT, though often used in many combinations of the DED tests, showed a remarkably high sensitivity and specificity on its own, as well as good correlation with DED related inflammation detected with conjunctival scraping cytology.http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501700185D.pdfdry eye syndromesconjunctivacytological techniquessensitivity and specificitydiagnostic tests, routinediagnosis, differential |
| spellingShingle | Dačić-Krnjaja Bojana Potić Jelena Raonić Danijela Stojković Milenko Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation Vojnosanitetski Pregled dry eye syndromes conjunctiva cytological techniques sensitivity and specificity diagnostic tests, routine diagnosis, differential |
| title | Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation |
| title_full | Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation |
| title_fullStr | Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation |
| title_full_unstemmed | Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation |
| title_short | Correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation |
| title_sort | correlation between conjunctival scraping cytology and other clinical dry eye metrics in determination of dry eye related inflammation |
| topic | dry eye syndromes conjunctiva cytological techniques sensitivity and specificity diagnostic tests, routine diagnosis, differential |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2019/0042-84501700185D.pdf |
| work_keys_str_mv | AT dacickrnjajabojana correlationbetweenconjunctivalscrapingcytologyandotherclinicaldryeyemetricsindeterminationofdryeyerelatedinflammation AT poticjelena correlationbetweenconjunctivalscrapingcytologyandotherclinicaldryeyemetricsindeterminationofdryeyerelatedinflammation AT raonicdanijela correlationbetweenconjunctivalscrapingcytologyandotherclinicaldryeyemetricsindeterminationofdryeyerelatedinflammation AT stojkovicmilenko correlationbetweenconjunctivalscrapingcytologyandotherclinicaldryeyemetricsindeterminationofdryeyerelatedinflammation |