Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I Diabetes
Artificial intelligence techniques have been positioned in the resolution of problems in various areas of healthcare. Clinical decision support systems developed from this technology have optimized the healthcare of patients with chronic diseases through mobile applications. In this study, several m...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/7326073 |
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| author | Guillermo Edinson Guzman Gómez Luis Eduardo Burbano Agredo Veline Martínez Oscar Fernando Bedoya Leiva |
| author_facet | Guillermo Edinson Guzman Gómez Luis Eduardo Burbano Agredo Veline Martínez Oscar Fernando Bedoya Leiva |
| author_sort | Guillermo Edinson Guzman Gómez |
| collection | DOAJ |
| description | Artificial intelligence techniques have been positioned in the resolution of problems in various areas of healthcare. Clinical decision support systems developed from this technology have optimized the healthcare of patients with chronic diseases through mobile applications. In this study, several models based on this methodology have been developed to calculate the basal insulin dose in patients with type I diabetes using subcutaneous insulin infusion pumps. Methods. A pilot experimental study was performed with data from 56 patients with type 1 diabetes who used insulin infusion pumps and underwent continuous glucose monitoring. Several models based on artificial intelligence techniques were developed to analyze glycemic patterns based on continuous glucose monitoring and clinical variables in order to estimate the basal insulin dose. We used neural networks (NNs), Bayesian networks (BNs), support vector machines (SVMs), and random forests (RF). We then evaluated the agreement between predicted and actual values using several statistical error measurements: mean absolute error (MAE), mean square error (MSE), root-mean-square error (RMSE), Pearson’s correlation coefficient (R), and determination coefficient (R2). Results. Twenty-four different models were obtained, one for each hour of the day, with each chosen technique. Correlation coefficients obtained with RF, SVMs, NNs, and BNs were 0.9999, 0.9921, 0.0303, and 0.7754, respectively. The error increased between 06:00 and 07:00 and between 13:00 and 17:00. Conclusions. The performance of the RF technique was excellent and got very close to the actual values. Intelligence techniques could be used to predict basal insulin dose. However, it is necessary to explore the validity of the results and select the target population. Models that allow for more accurate levels of prediction should be further explored. |
| format | Article |
| id | doaj-art-656019df61b84dc887c3582b50f73f1a |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-656019df61b84dc887c3582b50f73f1a2025-08-20T02:06:39ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/73260737326073Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I DiabetesGuillermo Edinson Guzman Gómez0Luis Eduardo Burbano Agredo1Veline Martínez2Oscar Fernando Bedoya Leiva3Fundación Valle del Lili, Departamento de Endocrinología, Cali, ColombiaUniversidad del Valle, Cali, ColombiaUniversidad Icesi, Facultad de Ciencias de la Salud, Cali, ColombiaUniversidad del Valle, School of Computer Science and Systems Engineering, Cali, ColombiaArtificial intelligence techniques have been positioned in the resolution of problems in various areas of healthcare. Clinical decision support systems developed from this technology have optimized the healthcare of patients with chronic diseases through mobile applications. In this study, several models based on this methodology have been developed to calculate the basal insulin dose in patients with type I diabetes using subcutaneous insulin infusion pumps. Methods. A pilot experimental study was performed with data from 56 patients with type 1 diabetes who used insulin infusion pumps and underwent continuous glucose monitoring. Several models based on artificial intelligence techniques were developed to analyze glycemic patterns based on continuous glucose monitoring and clinical variables in order to estimate the basal insulin dose. We used neural networks (NNs), Bayesian networks (BNs), support vector machines (SVMs), and random forests (RF). We then evaluated the agreement between predicted and actual values using several statistical error measurements: mean absolute error (MAE), mean square error (MSE), root-mean-square error (RMSE), Pearson’s correlation coefficient (R), and determination coefficient (R2). Results. Twenty-four different models were obtained, one for each hour of the day, with each chosen technique. Correlation coefficients obtained with RF, SVMs, NNs, and BNs were 0.9999, 0.9921, 0.0303, and 0.7754, respectively. The error increased between 06:00 and 07:00 and between 13:00 and 17:00. Conclusions. The performance of the RF technique was excellent and got very close to the actual values. Intelligence techniques could be used to predict basal insulin dose. However, it is necessary to explore the validity of the results and select the target population. Models that allow for more accurate levels of prediction should be further explored.http://dx.doi.org/10.1155/2020/7326073 |
| spellingShingle | Guillermo Edinson Guzman Gómez Luis Eduardo Burbano Agredo Veline Martínez Oscar Fernando Bedoya Leiva Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I Diabetes International Journal of Endocrinology |
| title | Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I Diabetes |
| title_full | Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I Diabetes |
| title_fullStr | Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I Diabetes |
| title_full_unstemmed | Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I Diabetes |
| title_short | Application of Artificial Intelligence Techniques for the Estimation of Basal Insulin in Patients with Type I Diabetes |
| title_sort | application of artificial intelligence techniques for the estimation of basal insulin in patients with type i diabetes |
| url | http://dx.doi.org/10.1155/2020/7326073 |
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