Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed Rats
The aim of this study was to investigate the ameliorative effects of fish oil on hepatic injury in ethanol-fed rats based on the intestinal permeability and microbiota. Rats were assigned to 6 groups and fed either a control diet or an ethanol diet such as C (control), CF25 (control with 25% fish oi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/4694726 |
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| author | Jiun-Rong Chen Ya-Ling Chen Hsiang-Chi Peng Yu-An Lu Hsiao-Li Chuang Hsiao-Yun Chang Hsiao-Yun Wang Yu-Ju Su Suh-Ching Yang |
| author_facet | Jiun-Rong Chen Ya-Ling Chen Hsiang-Chi Peng Yu-An Lu Hsiao-Li Chuang Hsiao-Yun Chang Hsiao-Yun Wang Yu-Ju Su Suh-Ching Yang |
| author_sort | Jiun-Rong Chen |
| collection | DOAJ |
| description | The aim of this study was to investigate the ameliorative effects of fish oil on hepatic injury in ethanol-fed rats based on the intestinal permeability and microbiota. Rats were assigned to 6 groups and fed either a control diet or an ethanol diet such as C (control), CF25 (control with 25% fish oil), CF57 (control with 57% fish oil), E (ethanol), EF25 (ethanol with 25% fish oil), and EF57 (ethanol with 57% fish oil) groups. Rats were sacrificed at the end of 8 weeks. Plasma aspartate aminotransferase (AST) and aminotransferase (ALT) activities, hepatic cytokines, and plasma endotoxin levels were significantly higher in the E group. In addition, hepatic histopathological analysis scores in the E group were significantly elevated. Rats in the E group also showed increased intestinal permeability and decreased numbers of fecal Bifidobacterium. However, plasma AST and ALT activities and hepatic cytokine levels were significantly lower in the EF25 and EF57 groups. Histological changes and intestinal permeability were also improved in the EF25 and EF57 groups. The fecal Escherichia coli numbers were significantly lower, but fecal Bifidobacterium numbers were significantly higher in the EF25 and EF57 groups. |
| format | Article |
| id | doaj-art-655f37c0b1e747f0a7a47d5f8e777f8d |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-655f37c0b1e747f0a7a47d5f8e777f8d2025-08-20T02:06:40ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/46947264694726Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed RatsJiun-Rong Chen0Ya-Ling Chen1Hsiang-Chi Peng2Yu-An Lu3Hsiao-Li Chuang4Hsiao-Yun Chang5Hsiao-Yun Wang6Yu-Ju Su7Suh-Ching Yang8School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanDepartment of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan 333, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanNational Applied Research Laboratories, National Laboratory Animal Center, Taipei 115, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanThe aim of this study was to investigate the ameliorative effects of fish oil on hepatic injury in ethanol-fed rats based on the intestinal permeability and microbiota. Rats were assigned to 6 groups and fed either a control diet or an ethanol diet such as C (control), CF25 (control with 25% fish oil), CF57 (control with 57% fish oil), E (ethanol), EF25 (ethanol with 25% fish oil), and EF57 (ethanol with 57% fish oil) groups. Rats were sacrificed at the end of 8 weeks. Plasma aspartate aminotransferase (AST) and aminotransferase (ALT) activities, hepatic cytokines, and plasma endotoxin levels were significantly higher in the E group. In addition, hepatic histopathological analysis scores in the E group were significantly elevated. Rats in the E group also showed increased intestinal permeability and decreased numbers of fecal Bifidobacterium. However, plasma AST and ALT activities and hepatic cytokine levels were significantly lower in the EF25 and EF57 groups. Histological changes and intestinal permeability were also improved in the EF25 and EF57 groups. The fecal Escherichia coli numbers were significantly lower, but fecal Bifidobacterium numbers were significantly higher in the EF25 and EF57 groups.http://dx.doi.org/10.1155/2016/4694726 |
| spellingShingle | Jiun-Rong Chen Ya-Ling Chen Hsiang-Chi Peng Yu-An Lu Hsiao-Li Chuang Hsiao-Yun Chang Hsiao-Yun Wang Yu-Ju Su Suh-Ching Yang Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed Rats Gastroenterology Research and Practice |
| title | Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed Rats |
| title_full | Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed Rats |
| title_fullStr | Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed Rats |
| title_full_unstemmed | Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed Rats |
| title_short | Fish Oil Reduces Hepatic Injury by Maintaining Normal Intestinal Permeability and Microbiota in Chronic Ethanol-Fed Rats |
| title_sort | fish oil reduces hepatic injury by maintaining normal intestinal permeability and microbiota in chronic ethanol fed rats |
| url | http://dx.doi.org/10.1155/2016/4694726 |
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