Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysis
Introduction. Genetic predisposition in combination with environmental factors and the patient’s psychological and emotional state play a key role in the development of irritable bowel syndrome (IBS). Studies of association between genetic polymorphisms and IBS can help in understanding the key path...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2024-08-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/959 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860048136241152 |
|---|---|
| author | E. A. Trush A. E. Karchevskaya R. V. Maslennikov E. A. Poluektova O. S. Shifrin V. T. Ivashkin |
| author_facet | E. A. Trush A. E. Karchevskaya R. V. Maslennikov E. A. Poluektova O. S. Shifrin V. T. Ivashkin |
| author_sort | E. A. Trush |
| collection | DOAJ |
| description | Introduction. Genetic predisposition in combination with environmental factors and the patient’s psychological and emotional state play a key role in the development of irritable bowel syndrome (IBS). Studies of association between genetic polymorphisms and IBS can help in understanding the key pathophysiological mechanisms. To date, 11 meta-analyses on this issue have been published, however, none of them comprehensively summarize the data on the prevalence of genetic polymorphisms in IBS with predominant constipation (IBS-C).Aim: to summarize the published data on the impact of genetic polymorphisms on the risk of IBS-C.Materials and methods. A literature search was performed in the PubMed and Scopus databases. Identified studies were used for a meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Publications investigating genetic polymorphisms in patients with IBS-C were included in this analysis.Results. A total of 34 studies met the inclusion criteria. The collected data were sufficient to conduct a meta-analysis on polymorphisms of three of the listed genes: SLC6A4 (10 articles), GNB3 (5 articles), ADRA2A (4 articles). No significant association was found between the SLC6A4 (5-HTTLPR) polymorphism, GNB3 c.825C > T (rs5443) polymorphism and either IBS or IBS-C. It was found that ADRA2A 1291C>G polymorphism was significantly associated with both IBS and IBS-C.Conclusions. Our meta-analysis revealed that ADRA2A 1291C>G polymorphism was significantly associated with both IBS and IBS-C in the mixed population. Neither homozygous nor heterozygous variants of the SLC6A4 (5-HTTLPR) polymorphism and GNB3 C825T polymorphism were associated with either IBS-C or IBS as a whole. |
| format | Article |
| id | doaj-art-655c2e893d2e4e149ff5a23795db5a8a |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2024-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-655c2e893d2e4e149ff5a23795db5a8a2025-02-10T16:14:39ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732024-08-01343627710.22416/1382-4376-2024-34-3-62-77923Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta AnalysisE. A. Trush0A. E. Karchevskaya1R. V. Maslennikov2E. A. Poluektova3O. S. Shifrin4V. T. Ivashkin5I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Introduction. Genetic predisposition in combination with environmental factors and the patient’s psychological and emotional state play a key role in the development of irritable bowel syndrome (IBS). Studies of association between genetic polymorphisms and IBS can help in understanding the key pathophysiological mechanisms. To date, 11 meta-analyses on this issue have been published, however, none of them comprehensively summarize the data on the prevalence of genetic polymorphisms in IBS with predominant constipation (IBS-C).Aim: to summarize the published data on the impact of genetic polymorphisms on the risk of IBS-C.Materials and methods. A literature search was performed in the PubMed and Scopus databases. Identified studies were used for a meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Publications investigating genetic polymorphisms in patients with IBS-C were included in this analysis.Results. A total of 34 studies met the inclusion criteria. The collected data were sufficient to conduct a meta-analysis on polymorphisms of three of the listed genes: SLC6A4 (10 articles), GNB3 (5 articles), ADRA2A (4 articles). No significant association was found between the SLC6A4 (5-HTTLPR) polymorphism, GNB3 c.825C > T (rs5443) polymorphism and either IBS or IBS-C. It was found that ADRA2A 1291C>G polymorphism was significantly associated with both IBS and IBS-C.Conclusions. Our meta-analysis revealed that ADRA2A 1291C>G polymorphism was significantly associated with both IBS and IBS-C in the mixed population. Neither homozygous nor heterozygous variants of the SLC6A4 (5-HTTLPR) polymorphism and GNB3 C825T polymorphism were associated with either IBS-C or IBS as a whole.https://www.gastro-j.ru/jour/article/view/959genetic susceptibilitygenetic polymorphismsconstipationirritable bowel syndrome5-httlpr polymorphism |
| spellingShingle | E. A. Trush A. E. Karchevskaya R. V. Maslennikov E. A. Poluektova O. S. Shifrin V. T. Ivashkin Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysis Российский журнал гастроэнтерологии, гепатологии, колопроктологии genetic susceptibility genetic polymorphisms constipation irritable bowel syndrome 5-httlpr polymorphism |
| title | Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysis |
| title_full | Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysis |
| title_fullStr | Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysis |
| title_full_unstemmed | Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysis |
| title_short | Single Nucleotide Polymorphisms, Associated with Increased Risk of Irritable Bowel Syndrome with Predominant Constipation: A Meta Analysis |
| title_sort | single nucleotide polymorphisms associated with increased risk of irritable bowel syndrome with predominant constipation a meta analysis |
| topic | genetic susceptibility genetic polymorphisms constipation irritable bowel syndrome 5-httlpr polymorphism |
| url | https://www.gastro-j.ru/jour/article/view/959 |
| work_keys_str_mv | AT eatrush singlenucleotidepolymorphismsassociatedwithincreasedriskofirritablebowelsyndromewithpredominantconstipationametaanalysis AT aekarchevskaya singlenucleotidepolymorphismsassociatedwithincreasedriskofirritablebowelsyndromewithpredominantconstipationametaanalysis AT rvmaslennikov singlenucleotidepolymorphismsassociatedwithincreasedriskofirritablebowelsyndromewithpredominantconstipationametaanalysis AT eapoluektova singlenucleotidepolymorphismsassociatedwithincreasedriskofirritablebowelsyndromewithpredominantconstipationametaanalysis AT osshifrin singlenucleotidepolymorphismsassociatedwithincreasedriskofirritablebowelsyndromewithpredominantconstipationametaanalysis AT vtivashkin singlenucleotidepolymorphismsassociatedwithincreasedriskofirritablebowelsyndromewithpredominantconstipationametaanalysis |