Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
Objective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults.Design Retrospective case-control study.Setting Cases from the substance unit and controls from a representative sample of the adult ge...
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| Format: | Article |
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BMJ Publishing Group
2019-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/9/e030328.full |
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| author | Ronald C Kessler Jose Maria Huerta Fernando Navarro-Mateu Mari Paz Quesada Teresa Escámez Mª José Alcaráz Catherine Seiquer de la Peña Diego Salmerón Gemma Vilagut Maria Dolores Chirlaque Carmen Navarro Mathilde Husky Jordi Alonso Salvador Martínez |
| author_facet | Ronald C Kessler Jose Maria Huerta Fernando Navarro-Mateu Mari Paz Quesada Teresa Escámez Mª José Alcaráz Catherine Seiquer de la Peña Diego Salmerón Gemma Vilagut Maria Dolores Chirlaque Carmen Navarro Mathilde Husky Jordi Alonso Salvador Martínez |
| author_sort | Ronald C Kessler |
| collection | DOAJ |
| description | Objective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults.Design Retrospective case-control study.Setting Cases from the substance unit and controls from a representative sample of the adult general population in the metropolitan area of Murcia (Spain).Participants Cases were defined as outpatients 18 years old or older currently in the treatment for alcohol, opioids or cocaine use disorders in the clinical unit. Controls were randomly selected among individuals without substance use disorders who participated in the Psychiatric Enquiry to General Population in Southeast Spain-Murcia (PEGASUS-Murcia) project, a cross-sectional study of a representative sample of the adult general population. In all, 142 cases and 531 controls were interviewed and a subsample of 114 cases (80.3%) and 329 controls (62%) provided a biological sample.Exposure A history of 12 childhood adversities, lifetime mental disorders and sociodemographic variables was assessed with the Composite International Diagnostic Interview (CIDI)version 3.0). Buccal swabs were obtained to genotype the 5-HTTLPR polymorphism with the biallelic and the triallelic classification.Main outcome and measure Multivariable logistic regression models were performed to estimate adjusted ORs and 95% CI.Results Childhood adversities were associated with an elevated risk of substance use disorders (OR=5.77, 95% CI 3.46 to 9.61). Homozygotes for the short allele of the 5-HTTLPR polymorphism also showed the elevated risk of substance use disorders for the biallelic and triallelic classification: (1.97 (1.10 to 3.55) and 2.01 (1.11 to 3.64), respectively). No evidence for gene × environment interactions was found.Conclusions Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene–environment interaction were inconclusive. |
| format | Article |
| id | doaj-art-655be575ec6b43d9816a7f8f00fae319 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-655be575ec6b43d9816a7f8f00fae3192025-08-20T02:06:46ZengBMJ Publishing GroupBMJ Open2044-60552019-09-019910.1136/bmjopen-2019-030328Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)Ronald C Kessler0Jose Maria Huerta1Fernando Navarro-Mateu2Mari Paz Quesada3Teresa Escámez4Mª José Alcaráz5Catherine Seiquer de la Peña6Diego Salmerón7Gemma Vilagut8Maria Dolores Chirlaque9Carmen Navarro10Mathilde Husky11Jordi Alonso12Salvador Martínez1312 Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA3 CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia, Spain3 CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia, Spain4 Cellular Therapy and Hematopoietic Transplant Unit, Hematology Department, IMIB-Arrixaca, Murcia, Spain5 Biobanco-HUVA-AECC-FFIS, IMIB BIOBANCA-MUR, Murcia, Spain6 Fundación para la Formación e Investigación Sanitarias de la Región de Murcia, Murcia, Spain7 Centro de Atención a Drogodependientes de Murcia, Servicio Murciano de Salud, Murcia, Spain8 Departamento de Ciencias Sociosanitarias, Universidad de Murcia, Murcia, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Granada, Spain9 Department of Epidemiology, Murcia Health Council, Murcia, Spain11 Laboratoire de Psychologie, Universite de Bordeaux, Bordeaux, Francegeneral practitioner13 Instituto de Neurociencias, UMH-CSIC, Alicante, SpainObjective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults.Design Retrospective case-control study.Setting Cases from the substance unit and controls from a representative sample of the adult general population in the metropolitan area of Murcia (Spain).Participants Cases were defined as outpatients 18 years old or older currently in the treatment for alcohol, opioids or cocaine use disorders in the clinical unit. Controls were randomly selected among individuals without substance use disorders who participated in the Psychiatric Enquiry to General Population in Southeast Spain-Murcia (PEGASUS-Murcia) project, a cross-sectional study of a representative sample of the adult general population. In all, 142 cases and 531 controls were interviewed and a subsample of 114 cases (80.3%) and 329 controls (62%) provided a biological sample.Exposure A history of 12 childhood adversities, lifetime mental disorders and sociodemographic variables was assessed with the Composite International Diagnostic Interview (CIDI)version 3.0). Buccal swabs were obtained to genotype the 5-HTTLPR polymorphism with the biallelic and the triallelic classification.Main outcome and measure Multivariable logistic regression models were performed to estimate adjusted ORs and 95% CI.Results Childhood adversities were associated with an elevated risk of substance use disorders (OR=5.77, 95% CI 3.46 to 9.61). Homozygotes for the short allele of the 5-HTTLPR polymorphism also showed the elevated risk of substance use disorders for the biallelic and triallelic classification: (1.97 (1.10 to 3.55) and 2.01 (1.11 to 3.64), respectively). No evidence for gene × environment interactions was found.Conclusions Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene–environment interaction were inconclusive.https://bmjopen.bmj.com/content/9/9/e030328.full |
| spellingShingle | Ronald C Kessler Jose Maria Huerta Fernando Navarro-Mateu Mari Paz Quesada Teresa Escámez Mª José Alcaráz Catherine Seiquer de la Peña Diego Salmerón Gemma Vilagut Maria Dolores Chirlaque Carmen Navarro Mathilde Husky Jordi Alonso Salvador Martínez Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain) BMJ Open |
| title | Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain) |
| title_full | Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain) |
| title_fullStr | Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain) |
| title_full_unstemmed | Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain) |
| title_short | Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain) |
| title_sort | childhood adversities and 5 httlpr polymorphism as risk factors of substance use disorders retrospective case control study in murcia spain |
| url | https://bmjopen.bmj.com/content/9/9/e030328.full |
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