Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1
Type I interferon (IFN-I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but they also orchestrate the initial phases of th...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2013/580968 |
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| _version_ | 1832561847349280768 |
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| author | Adriano Boasso |
| author_facet | Adriano Boasso |
| author_sort | Adriano Boasso |
| collection | DOAJ |
| description | Type I interferon (IFN-I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but they also orchestrate the initial phases of the adaptive immune response and influence the quality of T cell immunity. During infection with the human immunodeficiency virus type 1 (HIV-1), the production of and response to IFN-I may be severely altered by the lymphotropic nature of the virus. In this review I consider the different aspects of virus sensing, IFN-I production, signalling, and effects on target cells, with a particular focus on the alterations observed following HIV-1 infection. |
| format | Article |
| id | doaj-art-6559f970b2804c7a9564c0609d117c19 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-6559f970b2804c7a9564c0609d117c192025-02-03T01:24:03ZengWileyScientifica2090-908X2013-01-01201310.1155/2013/580968580968Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1Adriano Boasso0Immunology Section, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UKType I interferon (IFN-I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but they also orchestrate the initial phases of the adaptive immune response and influence the quality of T cell immunity. During infection with the human immunodeficiency virus type 1 (HIV-1), the production of and response to IFN-I may be severely altered by the lymphotropic nature of the virus. In this review I consider the different aspects of virus sensing, IFN-I production, signalling, and effects on target cells, with a particular focus on the alterations observed following HIV-1 infection.http://dx.doi.org/10.1155/2013/580968 |
| spellingShingle | Adriano Boasso Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1 Scientifica |
| title | Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1 |
| title_full | Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1 |
| title_fullStr | Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1 |
| title_full_unstemmed | Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1 |
| title_short | Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1 |
| title_sort | type i interferon at the interface of antiviral immunity and immune regulation the curious case of hiv 1 |
| url | http://dx.doi.org/10.1155/2013/580968 |
| work_keys_str_mv | AT adrianoboasso typeiinterferonattheinterfaceofantiviralimmunityandimmuneregulationthecuriouscaseofhiv1 |