The role and research progress of serine metabolism in tumor cells
Serine is crucial for tumor initiation, progression, and adaptive immunity. Metabolic pathways for serine synthesis, acquisition, and utilization in tumors and tumor-associated cells are influenced by various physiological factors and the tumor microenvironment, leading to metabolic reprogramming an...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1509662/full |
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| _version_ | 1850216063047827456 |
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| author | Hanning Lyu Shuchang Bao Lingyun Cai Mengke Wang Yuxin Liu Yang Sun Xiaoyang Hu |
| author_facet | Hanning Lyu Shuchang Bao Lingyun Cai Mengke Wang Yuxin Liu Yang Sun Xiaoyang Hu |
| author_sort | Hanning Lyu |
| collection | DOAJ |
| description | Serine is crucial for tumor initiation, progression, and adaptive immunity. Metabolic pathways for serine synthesis, acquisition, and utilization in tumors and tumor-associated cells are influenced by various physiological factors and the tumor microenvironment, leading to metabolic reprogramming and amplification. Excessive serine metabolism promotes abnormal macromolecule biosynthesis, mitochondrial dysfunction, and epigenetic modifications, driving malignant transformation, proliferation, metastasis, immune suppression, and drug resistance in tumor cells. Restricting dietary serine intake or reducing the expression of serine synthetic enzymes can effectively slow tumor growth and extend patient survival. Consequently, targeting serine metabolism has emerged as a novel and promising research focus in cancer research. This paper reviews serine metabolic pathways and their roles in tumor development. It summarizes the influencing factors of serine metabolism. The article explores the significance of serine synthesis and metabolizing enzymes, along with related biomarkers, in tumor diagnosis and treatment, providing new insights for developing targeted therapies that modulate serine metabolism in cancer. |
| format | Article |
| id | doaj-art-6554046afd4c46abbf09e94ef7ea81ec |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-6554046afd4c46abbf09e94ef7ea81ec2025-08-20T02:08:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15096621509662The role and research progress of serine metabolism in tumor cellsHanning LyuShuchang BaoLingyun CaiMengke WangYuxin LiuYang SunXiaoyang HuSerine is crucial for tumor initiation, progression, and adaptive immunity. Metabolic pathways for serine synthesis, acquisition, and utilization in tumors and tumor-associated cells are influenced by various physiological factors and the tumor microenvironment, leading to metabolic reprogramming and amplification. Excessive serine metabolism promotes abnormal macromolecule biosynthesis, mitochondrial dysfunction, and epigenetic modifications, driving malignant transformation, proliferation, metastasis, immune suppression, and drug resistance in tumor cells. Restricting dietary serine intake or reducing the expression of serine synthetic enzymes can effectively slow tumor growth and extend patient survival. Consequently, targeting serine metabolism has emerged as a novel and promising research focus in cancer research. This paper reviews serine metabolic pathways and their roles in tumor development. It summarizes the influencing factors of serine metabolism. The article explores the significance of serine synthesis and metabolizing enzymes, along with related biomarkers, in tumor diagnosis and treatment, providing new insights for developing targeted therapies that modulate serine metabolism in cancer.https://www.frontiersin.org/articles/10.3389/fonc.2025.1509662/fullserine metabolismcancerone-carbon metabolismserine catabolismthe immunosuppressive microenvironment |
| spellingShingle | Hanning Lyu Shuchang Bao Lingyun Cai Mengke Wang Yuxin Liu Yang Sun Xiaoyang Hu The role and research progress of serine metabolism in tumor cells Frontiers in Oncology serine metabolism cancer one-carbon metabolism serine catabolism the immunosuppressive microenvironment |
| title | The role and research progress of serine metabolism in tumor cells |
| title_full | The role and research progress of serine metabolism in tumor cells |
| title_fullStr | The role and research progress of serine metabolism in tumor cells |
| title_full_unstemmed | The role and research progress of serine metabolism in tumor cells |
| title_short | The role and research progress of serine metabolism in tumor cells |
| title_sort | role and research progress of serine metabolism in tumor cells |
| topic | serine metabolism cancer one-carbon metabolism serine catabolism the immunosuppressive microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1509662/full |
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