Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities
Abstract Mitochondrial quality control (MQC) is a critical mechanism for maintaining mitochondrial function and cellular metabolic homeostasis, playing an essential role in the self-renewal, differentiation, and long-term stability of hematopoietic stem cells (HSCs). Recent research highlights the c...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04304-7 |
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| author | Yun Liao Stacia Octaviani Zhen Tian Samuel R. Wang Chunlan Huang Jian Huang |
| author_facet | Yun Liao Stacia Octaviani Zhen Tian Samuel R. Wang Chunlan Huang Jian Huang |
| author_sort | Yun Liao |
| collection | DOAJ |
| description | Abstract Mitochondrial quality control (MQC) is a critical mechanism for maintaining mitochondrial function and cellular metabolic homeostasis, playing an essential role in the self-renewal, differentiation, and long-term stability of hematopoietic stem cells (HSCs). Recent research highlights the central importance of MQC in HSC biology, particularly the roles of mitophagy, mitochondrial biogenesis, fission, fusion and mitochondrial transfer in regulating HSC function. Mitophagy ensures the removal of damaged mitochondria, maintaining low levels of reactive oxygen species (ROS) in HSCs, thereby preventing premature aging and functional decline. Concurrently, mitochondrial biogenesis adjusts key metabolic regulators such as mitochondrial transcription factor A (TFAM) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) to meet environmental demands, ensuring the metabolic needs of HSCs are met. Additionally, mitochondrial transfer, as an essential form of intercellular material exchange, facilitates the transfer of functional mitochondria from bone marrow stromal cells to HSCs, contributing to damage repair and metabolic support. Although existing studies have revealed the significance of MQC in maintaining HSC function, the precise molecular mechanisms and interactions among different regulatory pathways remain to be fully elucidated. Furthermore, the potential role of MQC dysfunction in hematopoietic disorders, including its involvement in disease progression and therapeutic resistance, is not yet fully understood. This review discusses the molecular mechanisms of MQC in HSCs, its functions under physiological and pathological conditions, and its potential therapeutic applications. By summarizing the current progress in this field, we aim to provide insights for further research and the development of innovative treatment strategies. |
| format | Article |
| id | doaj-art-654bae0e2c2d4e9a933c88bc44024842 |
| institution | OA Journals |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-654bae0e2c2d4e9a933c88bc440248422025-08-20T02:17:46ZengBMCStem Cell Research & Therapy1757-65122025-04-0116111910.1186/s13287-025-04304-7Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunitiesYun Liao0Stacia Octaviani1Zhen Tian2Samuel R. Wang3Chunlan Huang4Jian Huang5Coriell Institute for Medical ResearchCoriell Institute for Medical ResearchCoriell Institute for Medical ResearchRutgers Cancer InstituteStem Cell Immunity and Regeneration Key Laboratory of LuzhouCoriell Institute for Medical ResearchAbstract Mitochondrial quality control (MQC) is a critical mechanism for maintaining mitochondrial function and cellular metabolic homeostasis, playing an essential role in the self-renewal, differentiation, and long-term stability of hematopoietic stem cells (HSCs). Recent research highlights the central importance of MQC in HSC biology, particularly the roles of mitophagy, mitochondrial biogenesis, fission, fusion and mitochondrial transfer in regulating HSC function. Mitophagy ensures the removal of damaged mitochondria, maintaining low levels of reactive oxygen species (ROS) in HSCs, thereby preventing premature aging and functional decline. Concurrently, mitochondrial biogenesis adjusts key metabolic regulators such as mitochondrial transcription factor A (TFAM) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) to meet environmental demands, ensuring the metabolic needs of HSCs are met. Additionally, mitochondrial transfer, as an essential form of intercellular material exchange, facilitates the transfer of functional mitochondria from bone marrow stromal cells to HSCs, contributing to damage repair and metabolic support. Although existing studies have revealed the significance of MQC in maintaining HSC function, the precise molecular mechanisms and interactions among different regulatory pathways remain to be fully elucidated. Furthermore, the potential role of MQC dysfunction in hematopoietic disorders, including its involvement in disease progression and therapeutic resistance, is not yet fully understood. This review discusses the molecular mechanisms of MQC in HSCs, its functions under physiological and pathological conditions, and its potential therapeutic applications. By summarizing the current progress in this field, we aim to provide insights for further research and the development of innovative treatment strategies.https://doi.org/10.1186/s13287-025-04304-7Mitochondrial quality controlHematopoietic stem cellMitochondrial metabolismMitophagyMitochondrial biogenesisMitochondrial dynamics |
| spellingShingle | Yun Liao Stacia Octaviani Zhen Tian Samuel R. Wang Chunlan Huang Jian Huang Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities Stem Cell Research & Therapy Mitochondrial quality control Hematopoietic stem cell Mitochondrial metabolism Mitophagy Mitochondrial biogenesis Mitochondrial dynamics |
| title | Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities |
| title_full | Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities |
| title_fullStr | Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities |
| title_full_unstemmed | Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities |
| title_short | Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities |
| title_sort | mitochondrial quality control in hematopoietic stem cells mechanisms implications and therapeutic opportunities |
| topic | Mitochondrial quality control Hematopoietic stem cell Mitochondrial metabolism Mitophagy Mitochondrial biogenesis Mitochondrial dynamics |
| url | https://doi.org/10.1186/s13287-025-04304-7 |
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