Penfluridol synergizes with colistin to reverse colistin resistance in Gram-negative bacilli

Penfluridol synergizes with colistin to reverse colistin resistance in Gram-negative bacilli

Abstract The growing prevalence of antibiotic resistance in multidrug-resistant Gram-negative bacteria (MDR-GNB), exacerbated by the misuse of antibiotics, presents a critical global health challenge. Colistin, a last-resort antibiotic for severe MDR-GNB infections, has faced diminishing efficacy du...

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Bibliographic Details
Main Authors: Chawalit Chatupheeraphat, Noramon Kaewsai, Nuttapat Anuwongcharoen, Chuleeporn Phanus-umporn, Sudarat Pornsuwan, Warawan Eiamphungporn
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Gram-negative bacteria
Colistin resistance
Synergistic effect
Penfluridol
Antibiofilm
Drug repurposing
Online Access:https://doi.org/10.1038/s41598-025-01303-9
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