Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing
<b>Background</b>: Developing versatile dressings that offer wound protection, maintain a moist environment, and facilitate healing represents an important therapeutic approach for burn patients. <b>Objectives</b>: This study presents the development of new smart pH-sensitive...
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MDPI AG
2025-05-01
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| author | Elena-Emilia Tudoroiu Mădălina Georgiana Albu Kaya Cristina Elena Dinu-Pîrvu Lăcrămioara Popa Valentina Anuța Mădălina Ignat Emilia Visileanu Durmuș Alpaslan Kaya Răzvan Mihai Prisada Mihaela Violeta Ghica |
| author_facet | Elena-Emilia Tudoroiu Mădălina Georgiana Albu Kaya Cristina Elena Dinu-Pîrvu Lăcrămioara Popa Valentina Anuța Mădălina Ignat Emilia Visileanu Durmuș Alpaslan Kaya Răzvan Mihai Prisada Mihaela Violeta Ghica |
| author_sort | Elena-Emilia Tudoroiu |
| collection | DOAJ |
| description | <b>Background</b>: Developing versatile dressings that offer wound protection, maintain a moist environment, and facilitate healing represents an important therapeutic approach for burn patients. <b>Objectives</b>: This study presents the development of new smart pH-sensitive collagen-hydroxyethylcellulose films, incorporating naproxen and phenol red, designed to provide controlled drug release while enabling real-time pH monitoring for burn care. <b>Methods</b>: Biopolymeric films were prepared by the solvent-casting method using ethanol and glycerol as plasticizers. <b>Results</b>: Orange-colored films were thin, flexible, and easily peelable, with uniform, smooth, and nonporous morphology. Tensile strength varied from 0.61 N/mm<sup>2</sup> to 3.33 N/mm<sup>2</sup>, indicating improved mechanical properties with increasing collagen content, while wetting analysis indicated a hydrophilic surface with contact angle values between 17.61° and 75.51°. Maximum swelling occurred at pH 7.4, ranging from 5.65 g/g to 9.20 g/g and pH 8.5, with values from 4.74 g/g to 7.92 g/g, suggesting effective exudate absorption. In vitro degradation proved structural stability maintenance for at least one day, with more than 40% weight loss. Films presented a biphasic naproxen release profile with more than 75% of the drug released after 24 h, properly managing inflammation and pain on the first-day post-burn. The pH variation mimicking the stages of the healing process demonstrated the color transition from yellow (pH 5.5) to orange (pH 7.4) and finally to bright fuchsia (pH 8.5), enabling easy visual evaluation of the wound environment. <b>Conclusions</b>: New multifunctional films combine diagnostic and therapeutic functions, providing a promising platform for monitoring wound healing, making them suitable for real-time wound assessment. |
| format | Article |
| id | doaj-art-6538e45c4fd14eac967cede2172cddea |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Pharmaceuticals |
| spelling | doaj-art-6538e45c4fd14eac967cede2172cddea2025-08-20T03:14:29ZengMDPI AGPharmaceuticals1424-82472025-05-0118568910.3390/ph18050689Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound HealingElena-Emilia Tudoroiu0Mădălina Georgiana Albu Kaya1Cristina Elena Dinu-Pîrvu2Lăcrămioara Popa3Valentina Anuța4Mădălina Ignat5Emilia Visileanu6Durmuș Alpaslan Kaya7Răzvan Mihai Prisada8Mihaela Violeta Ghica9Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Collagen, Division of Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu Str., 031215 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Testing and Quality Control, Division of Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, 93 Ion Minulescu Str., 031215 Bucharest, RomaniaNational Research and Development Institute for Textiles and Leather, 16 Lucrețiu Pătrășcanu Str., 030508 Bucharest, RomaniaDepartment of Field Crops, Faculty of Agriculture, Hatay Mustafa Kemal University, 31034 Antakya-Hatay, TurkeyDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, RomaniaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania<b>Background</b>: Developing versatile dressings that offer wound protection, maintain a moist environment, and facilitate healing represents an important therapeutic approach for burn patients. <b>Objectives</b>: This study presents the development of new smart pH-sensitive collagen-hydroxyethylcellulose films, incorporating naproxen and phenol red, designed to provide controlled drug release while enabling real-time pH monitoring for burn care. <b>Methods</b>: Biopolymeric films were prepared by the solvent-casting method using ethanol and glycerol as plasticizers. <b>Results</b>: Orange-colored films were thin, flexible, and easily peelable, with uniform, smooth, and nonporous morphology. Tensile strength varied from 0.61 N/mm<sup>2</sup> to 3.33 N/mm<sup>2</sup>, indicating improved mechanical properties with increasing collagen content, while wetting analysis indicated a hydrophilic surface with contact angle values between 17.61° and 75.51°. Maximum swelling occurred at pH 7.4, ranging from 5.65 g/g to 9.20 g/g and pH 8.5, with values from 4.74 g/g to 7.92 g/g, suggesting effective exudate absorption. In vitro degradation proved structural stability maintenance for at least one day, with more than 40% weight loss. Films presented a biphasic naproxen release profile with more than 75% of the drug released after 24 h, properly managing inflammation and pain on the first-day post-burn. The pH variation mimicking the stages of the healing process demonstrated the color transition from yellow (pH 5.5) to orange (pH 7.4) and finally to bright fuchsia (pH 8.5), enabling easy visual evaluation of the wound environment. <b>Conclusions</b>: New multifunctional films combine diagnostic and therapeutic functions, providing a promising platform for monitoring wound healing, making them suitable for real-time wound assessment.https://www.mdpi.com/1424-8247/18/5/689smart polymeric dressingpH-sensitive filmsphenol red indicatorcolorimetric pH detectiondrug releaseburn wound healing |
| spellingShingle | Elena-Emilia Tudoroiu Mădălina Georgiana Albu Kaya Cristina Elena Dinu-Pîrvu Lăcrămioara Popa Valentina Anuța Mădălina Ignat Emilia Visileanu Durmuș Alpaslan Kaya Răzvan Mihai Prisada Mihaela Violeta Ghica Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing Pharmaceuticals smart polymeric dressing pH-sensitive films phenol red indicator colorimetric pH detection drug release burn wound healing |
| title | Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing |
| title_full | Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing |
| title_fullStr | Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing |
| title_full_unstemmed | Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing |
| title_short | Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing |
| title_sort | development of smart ph sensitive collagen hydroxyethylcellulose films with naproxen for burn wound healing |
| topic | smart polymeric dressing pH-sensitive films phenol red indicator colorimetric pH detection drug release burn wound healing |
| url | https://www.mdpi.com/1424-8247/18/5/689 |
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