Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse
Endogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and behavioral levels across species to coordinate activity, for example, sleep/wake cycles, metabolism, and learning and memory, with predictable environmental cycles. The 21st century has seen a dramatic rise in t...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/4723836 |
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| author | Aliza K. De Nobrega Lisa C. Lyons |
| author_facet | Aliza K. De Nobrega Lisa C. Lyons |
| author_sort | Aliza K. De Nobrega |
| collection | DOAJ |
| description | Endogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and behavioral levels across species to coordinate activity, for example, sleep/wake cycles, metabolism, and learning and memory, with predictable environmental cycles. The 21st century has seen a dramatic rise in the incidence of circadian and sleep disorders with globalization, technological advances, and the use of personal electronics. The circadian clock modulates alcohol- and drug-induced behaviors with circadian misalignment contributing to increased substance use and abuse. Invertebrate models, such as Drosophila melanogaster, have proven invaluable for the identification of genetic and molecular mechanisms underlying highly conserved processes including the circadian clock, drug tolerance, and reward systems. In this review, we highlight the contributions of Drosophila as a model system for understanding the bidirectional interactions between the circadian system and the drugs of abuse, alcohol and cocaine, and illustrate the highly conserved nature of these interactions between Drosophila and mammalian systems. Research in Drosophila provides mechanistic insights into the corresponding behaviors in higher organisms and can be used as a guide for targeted inquiries in mammals. |
| format | Article |
| id | doaj-art-65387c2b289c47a4958583ef2bede993 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-65387c2b289c47a4958583ef2bede9932025-08-20T02:06:39ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/47238364723836Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of AbuseAliza K. De Nobrega0Lisa C. Lyons1Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USADepartment of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USAEndogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and behavioral levels across species to coordinate activity, for example, sleep/wake cycles, metabolism, and learning and memory, with predictable environmental cycles. The 21st century has seen a dramatic rise in the incidence of circadian and sleep disorders with globalization, technological advances, and the use of personal electronics. The circadian clock modulates alcohol- and drug-induced behaviors with circadian misalignment contributing to increased substance use and abuse. Invertebrate models, such as Drosophila melanogaster, have proven invaluable for the identification of genetic and molecular mechanisms underlying highly conserved processes including the circadian clock, drug tolerance, and reward systems. In this review, we highlight the contributions of Drosophila as a model system for understanding the bidirectional interactions between the circadian system and the drugs of abuse, alcohol and cocaine, and illustrate the highly conserved nature of these interactions between Drosophila and mammalian systems. Research in Drosophila provides mechanistic insights into the corresponding behaviors in higher organisms and can be used as a guide for targeted inquiries in mammals.http://dx.doi.org/10.1155/2017/4723836 |
| spellingShingle | Aliza K. De Nobrega Lisa C. Lyons Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse Neural Plasticity |
| title | Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse |
| title_full | Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse |
| title_fullStr | Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse |
| title_full_unstemmed | Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse |
| title_short | Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse |
| title_sort | drosophila an emergent model for delineating interactions between the circadian clock and drugs of abuse |
| url | http://dx.doi.org/10.1155/2017/4723836 |
| work_keys_str_mv | AT alizakdenobrega drosophilaanemergentmodelfordelineatinginteractionsbetweenthecircadianclockanddrugsofabuse AT lisaclyons drosophilaanemergentmodelfordelineatinginteractionsbetweenthecircadianclockanddrugsofabuse |