Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes
We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/7682083 |
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| author | Kyu Hwan Kwack Hyeon-Woo Lee |
| author_facet | Kyu Hwan Kwack Hyeon-Woo Lee |
| author_sort | Kyu Hwan Kwack |
| collection | DOAJ |
| description | We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA. PGRN-mediated inhibition of T lymphocyte proliferation, as well as the induction of iTregs, was completely reversed by a TGF-β inhibitor or a Treg inhibitor. PGRN induced TGF-β secretion in the presence of PHA whereas it did not in the absence of PHA. Our findings indicate that PGRN suppresses T lymphocyte proliferation by enhancing the formation of iTregs from activated T lymphocytes in response to TGF-β. |
| format | Article |
| id | doaj-art-6537816bc49642ff9c1a93e58a5bc297 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6537816bc49642ff9c1a93e58a5bc2972025-02-03T01:10:39ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/76820837682083Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T LymphocytesKyu Hwan Kwack0Hyeon-Woo Lee1Institute of Oral Biology, School of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaInstitute of Oral Biology, School of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaWe have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA. PGRN-mediated inhibition of T lymphocyte proliferation, as well as the induction of iTregs, was completely reversed by a TGF-β inhibitor or a Treg inhibitor. PGRN induced TGF-β secretion in the presence of PHA whereas it did not in the absence of PHA. Our findings indicate that PGRN suppresses T lymphocyte proliferation by enhancing the formation of iTregs from activated T lymphocytes in response to TGF-β.http://dx.doi.org/10.1155/2017/7682083 |
| spellingShingle | Kyu Hwan Kwack Hyeon-Woo Lee Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes Mediators of Inflammation |
| title | Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes |
| title_full | Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes |
| title_fullStr | Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes |
| title_full_unstemmed | Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes |
| title_short | Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes |
| title_sort | progranulin inhibits human t lymphocyte proliferation by inducing the formation of regulatory t lymphocytes |
| url | http://dx.doi.org/10.1155/2017/7682083 |
| work_keys_str_mv | AT kyuhwankwack progranulininhibitshumantlymphocyteproliferationbyinducingtheformationofregulatorytlymphocytes AT hyeonwoolee progranulininhibitshumantlymphocyteproliferationbyinducingtheformationofregulatorytlymphocytes |