Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment

Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment

Liver-humanized chimeric mice (PXB-mice) are widely utilized for predicting human pharmacokinetics (PK) and as human disease models. However, residual metabolic activity of mouse hepatocytes in chimeric mice can interfere with accurate human PK estimation. Lipid nanoparticle (LNP)-formulated small i...

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Bibliographic Details
Main Authors: Kazuto Yamazaki, Kenji Kubara, Go Sugahara, Hiroki Muto, Masae Yamamoto, Yuji Mano, Kaoru Mitsuhashi, Chihiro Yamasaki, Yuji Ishida, Chise Tateno, Yuta Suzuki
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
siRNA
species specificity
lipid nanoparticle
chimeric mice
humanized livers
cytochrome P450 oxidoreductase
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000610
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