Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury
Acute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration of novel medicinal treatments for AKI management remains vital. Substances of medicine food homology...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1539886/full |
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| author | Ling Chen Ling Chen Ling Chen Yanyan Deng Jing Hu Xuezhong Gong |
| author_facet | Ling Chen Ling Chen Ling Chen Yanyan Deng Jing Hu Xuezhong Gong |
| author_sort | Ling Chen |
| collection | DOAJ |
| description | Acute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration of novel medicinal treatments for AKI management remains vital. Substances of medicine food homology (SMFH), referring to substances having characteristics of both food and medicine, have been applied in China for thousands years.They could be used for daily diets and body conditioning. Traditional Chinese medicine (TCM), with its naturally derived components and demonstrated effectiveness, presents distinctive benefits in AKI treatment. Numerous studies have shown that SMFH and TCM phytochemicals could function satisfactorily with nephroprotective effects and have a significant effect on alleviating AKI as well as its complications. In this review, the pathogenesis of AKI was illustrated. We concentrated on SMFH and TCM phytochemicals against AKI and tried to summarize the underlying mechanisms in various kinds of AKI, highlighting the crucial phytochemical components in AKI prevention and therapy. Besides, strategies for SMFH and TCM phytochemicals globalization are analysed. This review comprehensively reveals that SMFH and TCM phytochemicals exhibit promising potential for AKI intervention by targeting various signal pathways and targets, which would contribute to AKI’s cognition, preventive treatments, as well as global promotion. |
| format | Article |
| id | doaj-art-65271bd42fb144078b1b50f10f5ea685 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-65271bd42fb144078b1b50f10f5ea6852025-08-20T02:43:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15398861539886Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injuryLing Chen0Ling Chen1Ling Chen2Yanyan Deng3Jing Hu4Xuezhong Gong5Department of Nephrology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaAcute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration of novel medicinal treatments for AKI management remains vital. Substances of medicine food homology (SMFH), referring to substances having characteristics of both food and medicine, have been applied in China for thousands years.They could be used for daily diets and body conditioning. Traditional Chinese medicine (TCM), with its naturally derived components and demonstrated effectiveness, presents distinctive benefits in AKI treatment. Numerous studies have shown that SMFH and TCM phytochemicals could function satisfactorily with nephroprotective effects and have a significant effect on alleviating AKI as well as its complications. In this review, the pathogenesis of AKI was illustrated. We concentrated on SMFH and TCM phytochemicals against AKI and tried to summarize the underlying mechanisms in various kinds of AKI, highlighting the crucial phytochemical components in AKI prevention and therapy. Besides, strategies for SMFH and TCM phytochemicals globalization are analysed. This review comprehensively reveals that SMFH and TCM phytochemicals exhibit promising potential for AKI intervention by targeting various signal pathways and targets, which would contribute to AKI’s cognition, preventive treatments, as well as global promotion.https://www.frontiersin.org/articles/10.3389/fphar.2025.1539886/fullnephroprotective effectssubstances of medicine food homologytraditional Chinese medicinephytochemicalsacute kidney injury |
| spellingShingle | Ling Chen Ling Chen Ling Chen Yanyan Deng Jing Hu Xuezhong Gong Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury Frontiers in Pharmacology nephroprotective effects substances of medicine food homology traditional Chinese medicine phytochemicals acute kidney injury |
| title | Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury |
| title_full | Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury |
| title_fullStr | Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury |
| title_full_unstemmed | Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury |
| title_short | Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury |
| title_sort | nephroprotective effects of substances of medicine food homology and traditional chinese medicine phytochemicals against acute kidney injury |
| topic | nephroprotective effects substances of medicine food homology traditional Chinese medicine phytochemicals acute kidney injury |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1539886/full |
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