The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer
Abstract Background Advances in medical science improved cancer treatment outcomes, and radiotherapy became a common modality used by 50% of cancer patients. However, radiotherapy induces gastrointestinal distress, and it can severely impair patients’ quality of life. During irradiation, the gut mic...
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Springer
2025-06-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02992-4 |
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| author | Yeuni Yu Sun Park Jaewan Jeon Se-Hui Lee Hyeyun Kim Dongju Seo Minwoo Park Eunho Park Ji Young Kim Seong-Jun Cho Sunmi Jo Geumju Park Jin-Young Yang |
| author_facet | Yeuni Yu Sun Park Jaewan Jeon Se-Hui Lee Hyeyun Kim Dongju Seo Minwoo Park Eunho Park Ji Young Kim Seong-Jun Cho Sunmi Jo Geumju Park Jin-Young Yang |
| author_sort | Yeuni Yu |
| collection | DOAJ |
| description | Abstract Background Advances in medical science improved cancer treatment outcomes, and radiotherapy became a common modality used by 50% of cancer patients. However, radiotherapy induces gastrointestinal distress, and it can severely impair patients’ quality of life. During irradiation, the gut microbiome is critical in maintaining intestinal health and influences the body’s response. This study examines the alterations in the gut microbiome and serum metabolites of prostate cancer patients undergoing radiotherapy. We investigate the potential radioprotective effects of Alistipes (A.) onderdonkii. Methods Ten patients with prostate cancer receiving radiotherapy were included in this study. Fecal and serum samples were collected, and diarrhea symptoms were monitored along with each radiotherapy section. Results After radiotherapy, nine microbiomes and 129 serum metabolites displayed significant changes associated with irradiation-induced gastrointestinal toxicity. Dehydroascorbic acid and A. onderdonkii found a correlation in the analysis between metabolites and the microbiome. Administration of A. onderdonkii significantly improved survival and reduced intestinal damage in mice after radiation exposure, suggesting A. onderdonkii as a protective agent in radiotherapy. Conclusions This result highlights A. onderdonkii as a potential microbial candidate for mitigating irradiation-induced damage in the gastrointestinal tract. It appears to alleviate oxidative stress and support mucosal integrity, thereby promoting resistance to radiation-induced injury. Impact This finding establishes the foundation for developing microbiome-based therapeutics for the gut health of cancer patients undergoing radiotherapy. |
| format | Article |
| id | doaj-art-6522c8487c764c8eb65dade48ff2a758 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-6522c8487c764c8eb65dade48ff2a7582025-08-20T03:22:50ZengSpringerDiscover Oncology2730-60112025-06-0116111310.1007/s12672-025-02992-4The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancerYeuni Yu0Sun Park1Jaewan Jeon2Se-Hui Lee3Hyeyun Kim4Dongju Seo5Minwoo Park6Eunho Park7Ji Young Kim8Seong-Jun Cho9Sunmi Jo10Geumju Park11Jin-Young Yang12Biomedical Research Institute, Pusan National University School of MedicineDepartment of Integrated Biological Sciences, Pusan National UniversityDepartment of Radiation Oncology, Haeundae Paik Hospital, Inje University School of MedicineDepartment of Integrated Biological Sciences, Pusan National UniversityDepartment of Integrated Biological Sciences, Pusan National UniversityDepartment of Integrated Biological Sciences, Pusan National UniversityResearch Center, EBIOGEN Inc.Research Center, EBIOGEN Inc.Radiation Effects Research Section, Radiation Health Institute, Korea Hydro & Nuclear Power CO., LTDRadiation Effects Research Section, Radiation Health Institute, Korea Hydro & Nuclear Power CO., LTDDepartment of Radiation Oncology, Haeundae Paik Hospital, Inje University School of MedicineDepartment of Radiation Oncology, Haeundae Paik Hospital, Inje University School of MedicineDepartment of Integrated Biological Sciences, Pusan National UniversityAbstract Background Advances in medical science improved cancer treatment outcomes, and radiotherapy became a common modality used by 50% of cancer patients. However, radiotherapy induces gastrointestinal distress, and it can severely impair patients’ quality of life. During irradiation, the gut microbiome is critical in maintaining intestinal health and influences the body’s response. This study examines the alterations in the gut microbiome and serum metabolites of prostate cancer patients undergoing radiotherapy. We investigate the potential radioprotective effects of Alistipes (A.) onderdonkii. Methods Ten patients with prostate cancer receiving radiotherapy were included in this study. Fecal and serum samples were collected, and diarrhea symptoms were monitored along with each radiotherapy section. Results After radiotherapy, nine microbiomes and 129 serum metabolites displayed significant changes associated with irradiation-induced gastrointestinal toxicity. Dehydroascorbic acid and A. onderdonkii found a correlation in the analysis between metabolites and the microbiome. Administration of A. onderdonkii significantly improved survival and reduced intestinal damage in mice after radiation exposure, suggesting A. onderdonkii as a protective agent in radiotherapy. Conclusions This result highlights A. onderdonkii as a potential microbial candidate for mitigating irradiation-induced damage in the gastrointestinal tract. It appears to alleviate oxidative stress and support mucosal integrity, thereby promoting resistance to radiation-induced injury. Impact This finding establishes the foundation for developing microbiome-based therapeutics for the gut health of cancer patients undergoing radiotherapy.https://doi.org/10.1007/s12672-025-02992-4RadiotherapyDiarrheaGut microbiomeAlistipes onderdonkii |
| spellingShingle | Yeuni Yu Sun Park Jaewan Jeon Se-Hui Lee Hyeyun Kim Dongju Seo Minwoo Park Eunho Park Ji Young Kim Seong-Jun Cho Sunmi Jo Geumju Park Jin-Young Yang The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer Discover Oncology Radiotherapy Diarrhea Gut microbiome Alistipes onderdonkii |
| title | The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer |
| title_full | The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer |
| title_fullStr | The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer |
| title_full_unstemmed | The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer |
| title_short | The radioprotective role of human Alistipes onderdonkii identified by multi-omic analysis in patients with prostate cancer |
| title_sort | radioprotective role of human alistipes onderdonkii identified by multi omic analysis in patients with prostate cancer |
| topic | Radiotherapy Diarrhea Gut microbiome Alistipes onderdonkii |
| url | https://doi.org/10.1007/s12672-025-02992-4 |
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