The Role of MicroRNAs in Cardiac Stem Cells
Stem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. Among several stem cells used in the clinical setting, cardiac stem cells (CSCs) which reside in the myocardium and epicardium of the heart have been s...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/194894 |
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| author | Nima Purvis Andrew Bahn Rajesh Katare |
| author_facet | Nima Purvis Andrew Bahn Rajesh Katare |
| author_sort | Nima Purvis |
| collection | DOAJ |
| description | Stem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. Among several stem cells used in the clinical setting, cardiac stem cells (CSCs) which reside in the myocardium and epicardium of the heart have been shown to be an effective option for the source of stem cells. In normal circumstances, CSCs primarily function as a cell store to replace the physiologically depleted cardiovascular cells, while under the diseased condition they have been shown to experimentally regenerate the diseased myocardium. In spite of their major functional role, molecular mechanisms regulating the CSCs proliferation and differentiation are still unknown. MicroRNAs (miRs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. Recent studies have demonstrated the important role of miRs in regulating stem cell proliferation and differentiation, as well as other physiological and pathological processes related to stem cell function. This review summarises the current understanding of the role of miRs in CSCs. A deeper understanding of the mechanisms by which miRs regulate CSCs may lead to advances in the mode of stem cell therapies for the treatment of cardiovascular diseases. |
| format | Article |
| id | doaj-art-6520e91213a5460781962a292038ee53 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6520e91213a5460781962a292038ee532025-02-03T05:58:41ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/194894194894The Role of MicroRNAs in Cardiac Stem CellsNima Purvis0Andrew Bahn1Rajesh Katare2Department of Physiology-Heart Otago, Otago School of Medical Sciences, University of Otago, Dunedin 9010, New ZealandDepartment of Physiology-Heart Otago, Otago School of Medical Sciences, University of Otago, Dunedin 9010, New ZealandDepartment of Physiology-Heart Otago, Otago School of Medical Sciences, University of Otago, Dunedin 9010, New ZealandStem cells are considered as the next generation drug treatment in patients with cardiovascular disease who are resistant to conventional treatment. Among several stem cells used in the clinical setting, cardiac stem cells (CSCs) which reside in the myocardium and epicardium of the heart have been shown to be an effective option for the source of stem cells. In normal circumstances, CSCs primarily function as a cell store to replace the physiologically depleted cardiovascular cells, while under the diseased condition they have been shown to experimentally regenerate the diseased myocardium. In spite of their major functional role, molecular mechanisms regulating the CSCs proliferation and differentiation are still unknown. MicroRNAs (miRs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. Recent studies have demonstrated the important role of miRs in regulating stem cell proliferation and differentiation, as well as other physiological and pathological processes related to stem cell function. This review summarises the current understanding of the role of miRs in CSCs. A deeper understanding of the mechanisms by which miRs regulate CSCs may lead to advances in the mode of stem cell therapies for the treatment of cardiovascular diseases.http://dx.doi.org/10.1155/2015/194894 |
| spellingShingle | Nima Purvis Andrew Bahn Rajesh Katare The Role of MicroRNAs in Cardiac Stem Cells Stem Cells International |
| title | The Role of MicroRNAs in Cardiac Stem Cells |
| title_full | The Role of MicroRNAs in Cardiac Stem Cells |
| title_fullStr | The Role of MicroRNAs in Cardiac Stem Cells |
| title_full_unstemmed | The Role of MicroRNAs in Cardiac Stem Cells |
| title_short | The Role of MicroRNAs in Cardiac Stem Cells |
| title_sort | role of micrornas in cardiac stem cells |
| url | http://dx.doi.org/10.1155/2015/194894 |
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