Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient
Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56 yr old...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/7984032 |
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| author | Gabriel Moreno-González Antoni Ricart de Mesones Rachid Tazi-Mezalek Maria Teresa Marron-Moya Antoni Rosell Rafael Mañez |
| author_facet | Gabriel Moreno-González Antoni Ricart de Mesones Rachid Tazi-Mezalek Maria Teresa Marron-Moya Antoni Rosell Rafael Mañez |
| author_sort | Gabriel Moreno-González |
| collection | DOAJ |
| description | Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. In the first 24 hours she developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission. A severe obstructive pattern with impossibility of ventilation because of bilateral atelectasis was observed, requiring emergent venovenous extracorporeal membrane oxygenator device insertion. Bronchoscopy revealed occlusion of main bronchi, demonstrating by biopsy an invasive infection by Aspergillus fumigatus and A. flavus. Despite an aggressive treatment and vital support the patient had a fatal outcome. The forensic study confirms the diagnosis of IPA but also revealed the presence of disseminated aspergillosis. |
| format | Article |
| id | doaj-art-6520737dce044ff695847e439e8b0e6c |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-6520737dce044ff695847e439e8b0e6c2025-02-03T06:47:25ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/79840327984032Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent PatientGabriel Moreno-González0Antoni Ricart de Mesones1Rachid Tazi-Mezalek2Maria Teresa Marron-Moya3Antoni Rosell4Rafael Mañez5Intensive Care Unit, Bellvitge University Hospital, Feixa Llarga, S/N, Hospitalet de Llobregat, 08907 Barcelona, SpainIntensive Care Unit, Bellvitge University Hospital, Feixa Llarga, S/N, Hospitalet de Llobregat, 08907 Barcelona, SpainBronchoscopy Department, Bellvitge University Hospital, Feixa Llarga, S/N, Hospitalet de Llobregat, 08907 Barcelona, SpainForensic Laboratory, Institute of Legal Medicine of Catalunya, Gran Via de les Corts Catalanes 111, 08075 Barcelona, SpainBronchoscopy Department, Bellvitge University Hospital, Feixa Llarga, S/N, Hospitalet de Llobregat, 08907 Barcelona, SpainIntensive Care Unit, Bellvitge University Hospital, Feixa Llarga, S/N, Hospitalet de Llobregat, 08907 Barcelona, SpainInvasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56 yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. In the first 24 hours she developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission. A severe obstructive pattern with impossibility of ventilation because of bilateral atelectasis was observed, requiring emergent venovenous extracorporeal membrane oxygenator device insertion. Bronchoscopy revealed occlusion of main bronchi, demonstrating by biopsy an invasive infection by Aspergillus fumigatus and A. flavus. Despite an aggressive treatment and vital support the patient had a fatal outcome. The forensic study confirms the diagnosis of IPA but also revealed the presence of disseminated aspergillosis.http://dx.doi.org/10.1155/2016/7984032 |
| spellingShingle | Gabriel Moreno-González Antoni Ricart de Mesones Rachid Tazi-Mezalek Maria Teresa Marron-Moya Antoni Rosell Rafael Mañez Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient Canadian Respiratory Journal |
| title | Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient |
| title_full | Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient |
| title_fullStr | Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient |
| title_full_unstemmed | Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient |
| title_short | Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient |
| title_sort | invasive pulmonary aspergillosis with disseminated infection in immunocompetent patient |
| url | http://dx.doi.org/10.1155/2016/7984032 |
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