Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury
In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensor...
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/630932 |
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| author | Ji Cheol Shin Keung Nyun Kim Jeehyun Yoo Il-Sun Kim Seokhwan Yun Hyejin Lee Kwangsoo Jung Kyujin Hwang Miri Kim Il-Shin Lee Jeong Eun Shin Kook In Park |
| author_facet | Ji Cheol Shin Keung Nyun Kim Jeehyun Yoo Il-Sun Kim Seokhwan Yun Hyejin Lee Kwangsoo Jung Kyujin Hwang Miri Kim Il-Shin Lee Jeong Eun Shin Kook In Park |
| author_sort | Ji Cheol Shin |
| collection | DOAJ |
| description | In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensorimotor complete and 2 were motor complete and sensory incomplete. hNSPCs derived from the fetal telencephalon were grown as neurospheres and transplanted into the cord. In the control group, who did not receive cell implantation but were otherwise closely matched with the transplantation group, 15 patients with traumatic cervical SCI were included. At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity. The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A → C), 1 (A → B), and 2 (B → D), whereas only one patient in the control group showed improvement (A → B). Improvements included increased motor scores, recovery of motor levels, and responses to electrophysiological studies in the transplantation group. Therefore, the transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of modest neurological benefit up to 1 year after transplants. This trial is registered with Clinical Research Information Service (CRIS), Registration Number: KCT0000879. |
| format | Article |
| id | doaj-art-651fade161b241e48ccabcedb9db68bc |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-651fade161b241e48ccabcedb9db68bc2025-02-03T05:46:41ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/630932630932Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord InjuryJi Cheol Shin0Keung Nyun Kim1Jeehyun Yoo2Il-Sun Kim3Seokhwan Yun4Hyejin Lee5Kwangsoo Jung6Kyujin Hwang7Miri Kim8Il-Shin Lee9Jeong Eun Shin10Kook In Park11Department of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaDepartment of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaBK21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaBK21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaBK21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaBK21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaBK21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaDepartment of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul 120-752, Republic of KoreaIn a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensorimotor complete and 2 were motor complete and sensory incomplete. hNSPCs derived from the fetal telencephalon were grown as neurospheres and transplanted into the cord. In the control group, who did not receive cell implantation but were otherwise closely matched with the transplantation group, 15 patients with traumatic cervical SCI were included. At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity. The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A → C), 1 (A → B), and 2 (B → D), whereas only one patient in the control group showed improvement (A → B). Improvements included increased motor scores, recovery of motor levels, and responses to electrophysiological studies in the transplantation group. Therefore, the transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of modest neurological benefit up to 1 year after transplants. This trial is registered with Clinical Research Information Service (CRIS), Registration Number: KCT0000879.http://dx.doi.org/10.1155/2015/630932 |
| spellingShingle | Ji Cheol Shin Keung Nyun Kim Jeehyun Yoo Il-Sun Kim Seokhwan Yun Hyejin Lee Kwangsoo Jung Kyujin Hwang Miri Kim Il-Shin Lee Jeong Eun Shin Kook In Park Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury Neural Plasticity |
| title | Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury |
| title_full | Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury |
| title_fullStr | Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury |
| title_full_unstemmed | Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury |
| title_short | Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury |
| title_sort | clinical trial of human fetal brain derived neural stem progenitor cell transplantation in patients with traumatic cervical spinal cord injury |
| url | http://dx.doi.org/10.1155/2015/630932 |
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