Immunoregulatory function of Ganoderma spore oil in immunocompromised mice
Ganoderma lucidum as a Chinese traditional medicine has been used as a medicine and food for a very long time. Ganoderma spore oil, a sort of lipin extracted from Ganoderma spore (the reproductive organs of Ganoderma lucidum), is rich in ganodenic acid, unsaturated fatty acid, Reishi polysaccharides...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2013-03-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2012.11.067 |
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| Summary: | Ganoderma lucidum as a Chinese traditional medicine has been used as a medicine and food for a very long time. Ganoderma spore oil, a sort of lipin extracted from Ganoderma spore (the reproductive organs of Ganoderma lucidum), is rich in ganodenic acid, unsaturated fatty acid, Reishi polysaccharides and so forth. The reports on immunoregulation and antioxidation of Ganoderma spore oil are few at present. Cyclophosphamide (CPA) is a common antineoplastic agent which can cause immunodepression. In order to reduce clinically immunocompromised side effects caused by CPA, the immune-deficient mouse model was established to study the immunoregulation effect of Ganoderma spore oil on immunocompromised mice.Ganoderma spore oil was given to hypo-immune model induced by injecting Kunming mice with CPA. The mice were randomly divided into nomal control group, model control group, Ganoderma spore oil group. Ganoderma spore oil group accepted 0.01 mL/g of 150 mg/kg Ganoderma spore oil for 30 d. Normal control group and model control group were given corn oil of 0.01 mL/g for 30 d. Model control group and Ganoderma spore oil group were given 40 mg/kg CPA once a day for 1, 3, 5, 17, 19, 21 d respectively, to establish immune-deficient mouse model. Nomal control group was injected subcutaneously with normal saline. The spleen and thymus index, lymphocyte transformation and delayed-type hypersensitivity (DTH), hemolysin antibody level and hemolysin content, natural killer (NK) cell activity were measured at the 30th day.The results showed that compared with normal control group, the measured parameters were low for model control group. However, the related parameters for Ganoderma spore oil group were higher than model control group and the difference was obvious (P<0.05), indicating that the Ganoderma spore oil could increase the spleen index, thymus index, lymphocyte transformation and DTH level, and improve the content of serum hemolysin in immunocompromised mice. In addition, the Ganoderma spore oil had remarkable promoting effect on immune regulation of immunocompromised mice, including cell immunity, humoral immunity and non-specific immunity.These results indicate Ganoderma spore oil can stimulate both specific and non-specific immune function in mice, and enhance the immunoregulation functions of the immunocompromised mice according to the Chinese Theory Evaluating Procedure and Test Method of Health Foods. |
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| ISSN: | 1008-9209 2097-5155 |