Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients
Goal. To investigate the spectrum of microorganisms, the level of antimicrobial resistance and to assess their effect on the outcomes of bacteremia among COVID19 patients.Materials and methods. A retrospective analysis of potentially resistant bacteria detected in blood and the mortality rate among...
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Journal Infectology
2024-12-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1707 |
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| author | D. A. Gusev V. B. Musatov E. V. Karnaukhov K. V. Zhdanov S. A. Gordeeva A. V. Pavlov |
| author_facet | D. A. Gusev V. B. Musatov E. V. Karnaukhov K. V. Zhdanov S. A. Gordeeva A. V. Pavlov |
| author_sort | D. A. Gusev |
| collection | DOAJ |
| description | Goal. To investigate the spectrum of microorganisms, the level of antimicrobial resistance and to assess their effect on the outcomes of bacteremia among COVID19 patients.Materials and methods. A retrospective analysis of potentially resistant bacteria detected in blood and the mortality rate among COVID19 patients and patients with other diagnoses in the period from 01.01. – 12/31/2020.Results. In total, the analyzed pathogens were isolated from 168 patients, including 101 COVID19 patients (group 1) and 67 patients with other diagnoses (group 2). Bloodstream infection were more often detected among COVID19 patients (12.6 and 2.6 cases per 1000 patients, p<0.05). In group 1, the proportion of gram-negative pathogens was higher than in group 2 (63.8% and 52.1%, p=0.012). The most commonly pathogen in group 1 is K. pneumoniae (31.5%, 41 cultures), in group 2 – S. aureus (35.2%, 25 cultures). Of particular importance is the identification of A. baumannii (32 and 4 cultures, p<0.001) and E. faecium (24 and 4 cultures, p=0.003) in group 1; S. aureus (25 and 11 cultures, p<0.001) and E. coli (9 and 6 cultures, p=0.038) – in group 2. Three leading types of microorganisms in group 1 have a high level of resistance: 96.9% of A. baumannii and 81.6% of K. pneumoniae were resistant to carbapenems, 36.8% of E. faecium was VRE. In group 1, several (22.8% and 6.0%, p=0.004) and resistant (70.3% and 41.8%, p<0.001) microorganisms were detected more frequently. The mortality rate of patients was higher in group 1 (68.3% and 50.7%, p=0.022). The occurrence of a bloodstream infection caused by a potentially resistant microorganism in COVID19 patients is an unfavorable factor in the onset of death (p=0.022).Conclusion. COVID19 patients with bacteremia have a high level of polymicrobial associations with a predominance of gram-negative bacteria both in their composition and as a monoinfection. The isolated microorganisms have a high level of antimicrobial resistance, which must be taken into account when choosing antibiotics. |
| format | Article |
| id | doaj-art-651956face46426dbf7c52df4826e663 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-651956face46426dbf7c52df4826e6632025-08-20T03:44:20ZrusJournal InfectologyЖурнал инфектологии2072-67322024-12-01164323910.22625/2072-6732-2024-16-4-32-391182Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patientsD. A. Gusev0V. B. Musatov1E. V. Karnaukhov2K. V. Zhdanov3S. A. Gordeeva4A. V. Pavlov5Clinical Infectious Disease Hospital named after S.P. Botkin; National Medical Research Centre named after V.A. AlmazovClinical Infectious Disease Hospital named after S.P. Botkin; Saint-Petersburg State UniversityClinical Infectious Disease Hospital named after S.P. BotkinSaint-Petersburg State UniversityClinical Infectious Disease Hospital named after S.P. Botkin; North-Western State Medical University named after I.I. MechnikovClinical Infectious Disease Hospital named after S.P. BotkinGoal. To investigate the spectrum of microorganisms, the level of antimicrobial resistance and to assess their effect on the outcomes of bacteremia among COVID19 patients.Materials and methods. A retrospective analysis of potentially resistant bacteria detected in blood and the mortality rate among COVID19 patients and patients with other diagnoses in the period from 01.01. – 12/31/2020.Results. In total, the analyzed pathogens were isolated from 168 patients, including 101 COVID19 patients (group 1) and 67 patients with other diagnoses (group 2). Bloodstream infection were more often detected among COVID19 patients (12.6 and 2.6 cases per 1000 patients, p<0.05). In group 1, the proportion of gram-negative pathogens was higher than in group 2 (63.8% and 52.1%, p=0.012). The most commonly pathogen in group 1 is K. pneumoniae (31.5%, 41 cultures), in group 2 – S. aureus (35.2%, 25 cultures). Of particular importance is the identification of A. baumannii (32 and 4 cultures, p<0.001) and E. faecium (24 and 4 cultures, p=0.003) in group 1; S. aureus (25 and 11 cultures, p<0.001) and E. coli (9 and 6 cultures, p=0.038) – in group 2. Three leading types of microorganisms in group 1 have a high level of resistance: 96.9% of A. baumannii and 81.6% of K. pneumoniae were resistant to carbapenems, 36.8% of E. faecium was VRE. In group 1, several (22.8% and 6.0%, p=0.004) and resistant (70.3% and 41.8%, p<0.001) microorganisms were detected more frequently. The mortality rate of patients was higher in group 1 (68.3% and 50.7%, p=0.022). The occurrence of a bloodstream infection caused by a potentially resistant microorganism in COVID19 patients is an unfavorable factor in the onset of death (p=0.022).Conclusion. COVID19 patients with bacteremia have a high level of polymicrobial associations with a predominance of gram-negative bacteria both in their composition and as a monoinfection. The isolated microorganisms have a high level of antimicrobial resistance, which must be taken into account when choosing antibiotics.https://journal.niidi.ru/jofin/article/view/1707new coronavirus infectioncovid19bacteremiaetiologyresistant microorganismsmortality rate |
| spellingShingle | D. A. Gusev V. B. Musatov E. V. Karnaukhov K. V. Zhdanov S. A. Gordeeva A. V. Pavlov Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients Журнал инфектологии new coronavirus infection covid19 bacteremia etiology resistant microorganisms mortality rate |
| title | Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients |
| title_full | Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients |
| title_fullStr | Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients |
| title_full_unstemmed | Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients |
| title_short | Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients |
| title_sort | etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in covid 19 patients |
| topic | new coronavirus infection covid19 bacteremia etiology resistant microorganisms mortality rate |
| url | https://journal.niidi.ru/jofin/article/view/1707 |
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