Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency
Pyruvate dehydrogenase complex deficiency is a rare genetic disorder that can lead to severe metabolic consequences. We present the case of a young adult with pyruvate dehydrogenase complex deficiency who presented with progressive shortness of breath and subsequently required intubation in the sett...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2023-05-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0738 |
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| _version_ | 1850198075066286080 |
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| author | Madison B. Calder Kristen D. Kelley |
| author_facet | Madison B. Calder Kristen D. Kelley |
| author_sort | Madison B. Calder |
| collection | DOAJ |
| description | Pyruvate dehydrogenase complex deficiency is a rare genetic disorder that can lead to severe metabolic consequences. We present the case of a young adult with pyruvate dehydrogenase complex deficiency who presented with progressive shortness of breath and subsequently required intubation in the setting of severe lactic acidemia. After resuscitation and extubation, a targeted history identified that the patient had eaten 3 grilled cheese sandwiches just before admission. In these rarely encountered cases, both detailed clinical history-gathering as well as multidisciplinary provider coordination is essential in ultimately implementing specialized dietary recommendations and thus preventing accelerated morbidity and mortality. |
| format | Article |
| id | doaj-art-6510bcec29ce43e28d28facee4cfbf4f |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-6510bcec29ce43e28d28facee4cfbf4f2025-08-20T02:12:58ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642023-05-012510.7326/aimcc.2022.0738Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex DeficiencyMadison B. Calder0Kristen D. Kelley11Department of Internal Medicine, UC Davis Health, Sacramento, California1Department of Internal Medicine, UC Davis Health, Sacramento, CaliforniaPyruvate dehydrogenase complex deficiency is a rare genetic disorder that can lead to severe metabolic consequences. We present the case of a young adult with pyruvate dehydrogenase complex deficiency who presented with progressive shortness of breath and subsequently required intubation in the setting of severe lactic acidemia. After resuscitation and extubation, a targeted history identified that the patient had eaten 3 grilled cheese sandwiches just before admission. In these rarely encountered cases, both detailed clinical history-gathering as well as multidisciplinary provider coordination is essential in ultimately implementing specialized dietary recommendations and thus preventing accelerated morbidity and mortality.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0738 |
| spellingShingle | Madison B. Calder Kristen D. Kelley Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency Annals of Internal Medicine: Clinical Cases |
| title | Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency |
| title_full | Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency |
| title_fullStr | Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency |
| title_full_unstemmed | Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency |
| title_short | Sandwich-Associated Lactic Acidosis: A Case Report of a Young Adult With Pyruvate Dehydrogenase Complex Deficiency |
| title_sort | sandwich associated lactic acidosis a case report of a young adult with pyruvate dehydrogenase complex deficiency |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0738 |
| work_keys_str_mv | AT madisonbcalder sandwichassociatedlacticacidosisacasereportofayoungadultwithpyruvatedehydrogenasecomplexdeficiency AT kristendkelley sandwichassociatedlacticacidosisacasereportofayoungadultwithpyruvatedehydrogenasecomplexdeficiency |