Gene mutation in cancer patients with diabetes: a real-world retrospective cohort study
Abstract Background Diabetes mellitus (DM) exhibits a strong association with tumorigenesis, yet its impact on tumor gene mutations remains poorly understood. Consequently, the present study was conducted to delve into the influence of DM on tumor gene mutations. Methods This study enrolled 397 lung...
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BMC
2025-07-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-14511-3 |
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| author | Lei Yang Yang Li TingTing Zeng Meiling Long Yating Li Hongmei Yue DePeng Jiang |
| author_facet | Lei Yang Yang Li TingTing Zeng Meiling Long Yating Li Hongmei Yue DePeng Jiang |
| author_sort | Lei Yang |
| collection | DOAJ |
| description | Abstract Background Diabetes mellitus (DM) exhibits a strong association with tumorigenesis, yet its impact on tumor gene mutations remains poorly understood. Consequently, the present study was conducted to delve into the influence of DM on tumor gene mutations. Methods This study enrolled 397 lung adenocarcinoma (ADC), 312 colorectal cancer (CRC), and 210 breast cancer (BC) patients between 2016 and 2024. All participants underwent next-generation sequencing (NGS) to detect tumor mutation genes (including point mutations, insertion, deletion, inversion, and duplication) and had their clinical characteristics evaluated. Linear regression analysis and Spearman correlation analysis were carried out to evaluate the association between DM and tumor gene mutations. Results Herein, tumor patients with DM exhibited significantly lower genetic mutation rates than non-DM individuals across all analyzed cancer types: ADC (49.76% vs. 66.15%, p < 0.001), CRC (28.95% vs. 45.96%, p = 0.003), and BC (34.31% vs. 48.15%, p = 0.042). A history of smoking (OR = 5.250, 95% CI, 1.858–14.835, p = 0.002), clinical stage II (OR = 14.495, 95% CI: 4.860-43.227, p = 0.001), and stage IV (OR = 21.022, 95% CI: 3.753-117.761, p = 0.001) were associated with ADC gene mutations. For CRC, clinical stage II trended toward an association with gene mutations (OR = 4.021, 95%CI, 0.966–16.745, p = 0.056). In BC, WBC count were negatively correlated with BC gene mutations (OR = 0.675, 95%CI, 0.461–0.987, p = 0.043). Notably, DM was independently associated with a reduced likelihood of tumor gene mutations across all cancer types analyzed. Conclusion This study suggests that DM may lower the likelihood of genetic mutations in tumors, however, tumor gene mutations are influenced by multiple factors. |
| format | Article |
| id | doaj-art-650e1f5b4b2741d89ce764f73d54a5f3 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj-art-650e1f5b4b2741d89ce764f73d54a5f32025-08-20T03:45:56ZengBMCBMC Cancer1471-24072025-07-0125111310.1186/s12885-025-14511-3Gene mutation in cancer patients with diabetes: a real-world retrospective cohort studyLei Yang0Yang Li1TingTing Zeng2Meiling Long3Yating Li4Hongmei Yue5DePeng Jiang6Department of Respiratory Medicine, The first affiliated Hospital of Lanzhou UniversityDepartment of Respiratory Medicine, The second affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The Second affiliated Hospital of Chongqing Medical UniversityDepartment of Respiratory Medicine, The second affiliated Hospital of Chongqing Medical UniversityDepartment of Respiratory Medicine, The first affiliated Hospital of Lanzhou UniversityDepartment of Respiratory Medicine, The first affiliated Hospital of Lanzhou UniversityDepartment of Respiratory Medicine, The second affiliated Hospital of Chongqing Medical UniversityAbstract Background Diabetes mellitus (DM) exhibits a strong association with tumorigenesis, yet its impact on tumor gene mutations remains poorly understood. Consequently, the present study was conducted to delve into the influence of DM on tumor gene mutations. Methods This study enrolled 397 lung adenocarcinoma (ADC), 312 colorectal cancer (CRC), and 210 breast cancer (BC) patients between 2016 and 2024. All participants underwent next-generation sequencing (NGS) to detect tumor mutation genes (including point mutations, insertion, deletion, inversion, and duplication) and had their clinical characteristics evaluated. Linear regression analysis and Spearman correlation analysis were carried out to evaluate the association between DM and tumor gene mutations. Results Herein, tumor patients with DM exhibited significantly lower genetic mutation rates than non-DM individuals across all analyzed cancer types: ADC (49.76% vs. 66.15%, p < 0.001), CRC (28.95% vs. 45.96%, p = 0.003), and BC (34.31% vs. 48.15%, p = 0.042). A history of smoking (OR = 5.250, 95% CI, 1.858–14.835, p = 0.002), clinical stage II (OR = 14.495, 95% CI: 4.860-43.227, p = 0.001), and stage IV (OR = 21.022, 95% CI: 3.753-117.761, p = 0.001) were associated with ADC gene mutations. For CRC, clinical stage II trended toward an association with gene mutations (OR = 4.021, 95%CI, 0.966–16.745, p = 0.056). In BC, WBC count were negatively correlated with BC gene mutations (OR = 0.675, 95%CI, 0.461–0.987, p = 0.043). Notably, DM was independently associated with a reduced likelihood of tumor gene mutations across all cancer types analyzed. Conclusion This study suggests that DM may lower the likelihood of genetic mutations in tumors, however, tumor gene mutations are influenced by multiple factors.https://doi.org/10.1186/s12885-025-14511-3DiabetesGene mutationLung adenocarcinomaColorectal cancerBreast cancer |
| spellingShingle | Lei Yang Yang Li TingTing Zeng Meiling Long Yating Li Hongmei Yue DePeng Jiang Gene mutation in cancer patients with diabetes: a real-world retrospective cohort study BMC Cancer Diabetes Gene mutation Lung adenocarcinoma Colorectal cancer Breast cancer |
| title | Gene mutation in cancer patients with diabetes: a real-world retrospective cohort study |
| title_full | Gene mutation in cancer patients with diabetes: a real-world retrospective cohort study |
| title_fullStr | Gene mutation in cancer patients with diabetes: a real-world retrospective cohort study |
| title_full_unstemmed | Gene mutation in cancer patients with diabetes: a real-world retrospective cohort study |
| title_short | Gene mutation in cancer patients with diabetes: a real-world retrospective cohort study |
| title_sort | gene mutation in cancer patients with diabetes a real world retrospective cohort study |
| topic | Diabetes Gene mutation Lung adenocarcinoma Colorectal cancer Breast cancer |
| url | https://doi.org/10.1186/s12885-025-14511-3 |
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