Role of non-coding RNA-regulated ferroptosis in colorectal cancer
Abstract The recently discovered type of programmed cell death, termed ferroptosis, characterized by an iron-dependent accumulation of lipid peroxides, has been demonstrated to play a pivotal role in the progress of tumors. The role of non-coding RNAs (ncRNAs) in various malignant tumors has also be...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02606-6 |
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| author | Yan-Peng Zhao Jun-Liang Liu Shuai Wang Xue Li |
| author_facet | Yan-Peng Zhao Jun-Liang Liu Shuai Wang Xue Li |
| author_sort | Yan-Peng Zhao |
| collection | DOAJ |
| description | Abstract The recently discovered type of programmed cell death, termed ferroptosis, characterized by an iron-dependent accumulation of lipid peroxides, has been demonstrated to play a pivotal role in the progress of tumors. The role of non-coding RNAs (ncRNAs) in various malignant tumors has also been gradually elucidated in recent years. Colorectal cancer (CRC) is a malignant tumor with a high prevalence and mortality rate worldwide. Many recent studies have demonstrated that the effects of ncRNAs on CRC progression may be mediated by their regulation of ferroptosis. This review first outlines the fundamental mechanisms of ferroptosis and the role of ncRNAs in ferroptosis, and then we summarize the role of ferroptosis in CRC. We then focused on summarizing the effect of ncRNAs regulating ferroptosis in CRC and the recent progress of ferroptosis-related ncRNAs as prognostic biomarkers in CRC patients. This review will help to deepen our understanding of the ncRNA-ferroptosis-CRC axis and inform the study of potential therapeutic targets and prognostic markers for CRC patients. |
| format | Article |
| id | doaj-art-650dbc19fc704d54b10b7efb3e12fd7f |
| institution | DOAJ |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-650dbc19fc704d54b10b7efb3e12fd7f2025-08-20T03:04:22ZengNature Publishing GroupCell Death Discovery2058-77162025-07-0111111310.1038/s41420-025-02606-6Role of non-coding RNA-regulated ferroptosis in colorectal cancerYan-Peng Zhao0Jun-Liang Liu1Shuai Wang2Xue Li3Department of General Surgery, Central Hospital Affiliated to Shenyang Medical CollegeDepartment of General Surgery, Central Hospital Affiliated to Shenyang Medical CollegeDepartment of General Surgery, Central Hospital Affiliated to Shenyang Medical CollegeDepartment of General Surgery, Central Hospital Affiliated to Shenyang Medical CollegeAbstract The recently discovered type of programmed cell death, termed ferroptosis, characterized by an iron-dependent accumulation of lipid peroxides, has been demonstrated to play a pivotal role in the progress of tumors. The role of non-coding RNAs (ncRNAs) in various malignant tumors has also been gradually elucidated in recent years. Colorectal cancer (CRC) is a malignant tumor with a high prevalence and mortality rate worldwide. Many recent studies have demonstrated that the effects of ncRNAs on CRC progression may be mediated by their regulation of ferroptosis. This review first outlines the fundamental mechanisms of ferroptosis and the role of ncRNAs in ferroptosis, and then we summarize the role of ferroptosis in CRC. We then focused on summarizing the effect of ncRNAs regulating ferroptosis in CRC and the recent progress of ferroptosis-related ncRNAs as prognostic biomarkers in CRC patients. This review will help to deepen our understanding of the ncRNA-ferroptosis-CRC axis and inform the study of potential therapeutic targets and prognostic markers for CRC patients.https://doi.org/10.1038/s41420-025-02606-6 |
| spellingShingle | Yan-Peng Zhao Jun-Liang Liu Shuai Wang Xue Li Role of non-coding RNA-regulated ferroptosis in colorectal cancer Cell Death Discovery |
| title | Role of non-coding RNA-regulated ferroptosis in colorectal cancer |
| title_full | Role of non-coding RNA-regulated ferroptosis in colorectal cancer |
| title_fullStr | Role of non-coding RNA-regulated ferroptosis in colorectal cancer |
| title_full_unstemmed | Role of non-coding RNA-regulated ferroptosis in colorectal cancer |
| title_short | Role of non-coding RNA-regulated ferroptosis in colorectal cancer |
| title_sort | role of non coding rna regulated ferroptosis in colorectal cancer |
| url | https://doi.org/10.1038/s41420-025-02606-6 |
| work_keys_str_mv | AT yanpengzhao roleofnoncodingrnaregulatedferroptosisincolorectalcancer AT junliangliu roleofnoncodingrnaregulatedferroptosisincolorectalcancer AT shuaiwang roleofnoncodingrnaregulatedferroptosisincolorectalcancer AT xueli roleofnoncodingrnaregulatedferroptosisincolorectalcancer |