Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair
Myxomatous mitral valve disease (MMVD) in dogs can be treated with transcatheter edge-to-edge mitral valve repair (TEER), an emerging minimally invasive surgical technique. However, reports on prognostic markers for preoperative evaluation remain limited. This study evaluated the association of preo...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/12/3/223 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849339921800626176 |
|---|---|
| author | Jeong-Min Lee Seung-Keun Lee Kyoung-A Youp Ah-Ra Lee Young-Wook Cho Youn-Seo Jung Sun-Tae Lee |
| author_facet | Jeong-Min Lee Seung-Keun Lee Kyoung-A Youp Ah-Ra Lee Young-Wook Cho Youn-Seo Jung Sun-Tae Lee |
| author_sort | Jeong-Min Lee |
| collection | DOAJ |
| description | Myxomatous mitral valve disease (MMVD) in dogs can be treated with transcatheter edge-to-edge mitral valve repair (TEER), an emerging minimally invasive surgical technique. However, reports on prognostic markers for preoperative evaluation remain limited. This study evaluated the association of preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) levels with procedure safety in dogs undergoing TEER. A retrospective analysis was conducted on 25 dogs diagnosed with stage C (n = 18) or D (n = 7) MMVD that underwent TEER between September 2023 and January 2025. Preoperative NT-proBNP and cTnI values were measured and compared between survivors and non-survivors. Among the survivors, 15 and 4 dogs were stages C and D, respectively. Among the non-survivors, three and three dogs were stages C and D, respectively. Non-survivors had higher median NT-proBNP levels (3557 pmol/L; range: 774–10,000) and cTnI levels (0.39 ng/mL; range: 0.22–0.51) than survivors (NT-proBNP: 1262.6 pmol/L, range: 500–8773; cTnI: 0.1 ng/mL, range: 0.01–3.6). However, the two groups showed no significant differences in NT-proBNP (<i>p</i> = 0.187) or cTnI (<i>p</i> = 0.869). Increased preoperative NT-proBNP and cTnI levels were not strong predictors of procedure safety in dogs with MMVD stages C and D undergoing TEER. Further studies with larger sample sizes and longer follow-up periods are needed to better evaluate the prognostic value of these biomarkers in this population. |
| format | Article |
| id | doaj-art-64fac73b9e7f4fb7bd2bfc5e03868535 |
| institution | Kabale University |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-64fac73b9e7f4fb7bd2bfc5e038685352025-08-20T03:44:01ZengMDPI AGVeterinary Sciences2306-73812025-03-0112322310.3390/vetsci12030223Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve RepairJeong-Min Lee0Seung-Keun Lee1Kyoung-A Youp2Ah-Ra Lee3Young-Wook Cho4Youn-Seo Jung5Sun-Tae Lee6Korea Animal Medical Center, Cheongju 28651, Republic of KoreaKorea Animal Medical Center, Cheongju 28651, Republic of KoreaKorea Animal Medical Center, Cheongju 28651, Republic of KoreaKorea Animal Medical Center, Cheongju 28651, Republic of KoreaKorea Animal Medical Center, Cheongju 28651, Republic of KoreaKorea Animal Medical Center, Cheongju 28651, Republic of KoreaKorea Animal Medical Center, Cheongju 28651, Republic of KoreaMyxomatous mitral valve disease (MMVD) in dogs can be treated with transcatheter edge-to-edge mitral valve repair (TEER), an emerging minimally invasive surgical technique. However, reports on prognostic markers for preoperative evaluation remain limited. This study evaluated the association of preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) levels with procedure safety in dogs undergoing TEER. A retrospective analysis was conducted on 25 dogs diagnosed with stage C (n = 18) or D (n = 7) MMVD that underwent TEER between September 2023 and January 2025. Preoperative NT-proBNP and cTnI values were measured and compared between survivors and non-survivors. Among the survivors, 15 and 4 dogs were stages C and D, respectively. Among the non-survivors, three and three dogs were stages C and D, respectively. Non-survivors had higher median NT-proBNP levels (3557 pmol/L; range: 774–10,000) and cTnI levels (0.39 ng/mL; range: 0.22–0.51) than survivors (NT-proBNP: 1262.6 pmol/L, range: 500–8773; cTnI: 0.1 ng/mL, range: 0.01–3.6). However, the two groups showed no significant differences in NT-proBNP (<i>p</i> = 0.187) or cTnI (<i>p</i> = 0.869). Increased preoperative NT-proBNP and cTnI levels were not strong predictors of procedure safety in dogs with MMVD stages C and D undergoing TEER. Further studies with larger sample sizes and longer follow-up periods are needed to better evaluate the prognostic value of these biomarkers in this population.https://www.mdpi.com/2306-7381/12/3/223caninemyxomatous mitral valve diseasemitral valve repairtranscatheter edge-to-edge repair |
| spellingShingle | Jeong-Min Lee Seung-Keun Lee Kyoung-A Youp Ah-Ra Lee Young-Wook Cho Youn-Seo Jung Sun-Tae Lee Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair Veterinary Sciences canine myxomatous mitral valve disease mitral valve repair transcatheter edge-to-edge repair |
| title | Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair |
| title_full | Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair |
| title_fullStr | Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair |
| title_full_unstemmed | Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair |
| title_short | Preliminary Evaluation of NT-proBNP and cTnI as Predictors of Procedure Safety in Dogs Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair |
| title_sort | preliminary evaluation of nt probnp and ctni as predictors of procedure safety in dogs undergoing transcatheter edge to edge mitral valve repair |
| topic | canine myxomatous mitral valve disease mitral valve repair transcatheter edge-to-edge repair |
| url | https://www.mdpi.com/2306-7381/12/3/223 |
| work_keys_str_mv | AT jeongminlee preliminaryevaluationofntprobnpandctniaspredictorsofproceduresafetyindogsundergoingtranscatheteredgetoedgemitralvalverepair AT seungkeunlee preliminaryevaluationofntprobnpandctniaspredictorsofproceduresafetyindogsundergoingtranscatheteredgetoedgemitralvalverepair AT kyoungayoup preliminaryevaluationofntprobnpandctniaspredictorsofproceduresafetyindogsundergoingtranscatheteredgetoedgemitralvalverepair AT ahralee preliminaryevaluationofntprobnpandctniaspredictorsofproceduresafetyindogsundergoingtranscatheteredgetoedgemitralvalverepair AT youngwookcho preliminaryevaluationofntprobnpandctniaspredictorsofproceduresafetyindogsundergoingtranscatheteredgetoedgemitralvalverepair AT younseojung preliminaryevaluationofntprobnpandctniaspredictorsofproceduresafetyindogsundergoingtranscatheteredgetoedgemitralvalverepair AT suntaelee preliminaryevaluationofntprobnpandctniaspredictorsofproceduresafetyindogsundergoingtranscatheteredgetoedgemitralvalverepair |