Helicobacter pylori infection process: from the molecular world to clinical treatment
Helicobacter pylori is a gram-negative microaerophilic microorganism intricately associated with chronic gastrointestinal disorders and gastric cancer. H. pylori can cause various upper digestive tract diseases, including chronic gastritis, peptic ulcer, gastroesophageal reflux disease, and gastric...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1541140/full |
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| author | Meijing Yi Meijing Yi Silan Chen Silan Chen Xinying Yi Xinying Yi Fan Zhang Fan Zhang Xuan Zhou Xuan Zhou Meiyan Zeng Houpan Song Houpan Song |
| author_facet | Meijing Yi Meijing Yi Silan Chen Silan Chen Xinying Yi Xinying Yi Fan Zhang Fan Zhang Xuan Zhou Xuan Zhou Meiyan Zeng Houpan Song Houpan Song |
| author_sort | Meijing Yi |
| collection | DOAJ |
| description | Helicobacter pylori is a gram-negative microaerophilic microorganism intricately associated with chronic gastrointestinal disorders and gastric cancer. H. pylori can cause various upper digestive tract diseases, including chronic gastritis, peptic ulcer, gastroesophageal reflux disease, and gastric cancer. The bacterium exhibits a variety of pathogenic mechanisms, including colonization, the expression of virulence factors, and the development of drug resistance. This article presents a comprehensive review of H. pylori pathogenesis, emphasizing recent research advancements concerning the cytotoxin-associated gene A, vacuolating cytotoxin, outer membrane proteins, and other virulence factors. Additionally, it examines the molecular mechanisms underlying drug resistance and evaluates the efficacy of conventional therapeutic approaches. Recently, researchers have attempted novel therapeutic regimens, including probiotics and Chinese medicine-assisted therapies, to enhance therapeutic effects. This article aimed to offer an overview of the academic community’s comprehension of H. pylori infection and to highlight the current treatment options. |
| format | Article |
| id | doaj-art-64f7b8a3bcb2441aaa0f5a7c8779162b |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-64f7b8a3bcb2441aaa0f5a7c8779162b2025-08-20T02:03:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.15411401541140Helicobacter pylori infection process: from the molecular world to clinical treatmentMeijing Yi0Meijing Yi1Silan Chen2Silan Chen3Xinying Yi4Xinying Yi5Fan Zhang6Fan Zhang7Xuan Zhou8Xuan Zhou9Meiyan Zeng10Houpan Song11Houpan Song12School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, ChinaHelicobacter pylori is a gram-negative microaerophilic microorganism intricately associated with chronic gastrointestinal disorders and gastric cancer. H. pylori can cause various upper digestive tract diseases, including chronic gastritis, peptic ulcer, gastroesophageal reflux disease, and gastric cancer. The bacterium exhibits a variety of pathogenic mechanisms, including colonization, the expression of virulence factors, and the development of drug resistance. This article presents a comprehensive review of H. pylori pathogenesis, emphasizing recent research advancements concerning the cytotoxin-associated gene A, vacuolating cytotoxin, outer membrane proteins, and other virulence factors. Additionally, it examines the molecular mechanisms underlying drug resistance and evaluates the efficacy of conventional therapeutic approaches. Recently, researchers have attempted novel therapeutic regimens, including probiotics and Chinese medicine-assisted therapies, to enhance therapeutic effects. This article aimed to offer an overview of the academic community’s comprehension of H. pylori infection and to highlight the current treatment options.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1541140/fullHelicobacter pyloripathogenic mechanismtreatmentantibiotic resistanceprobiotics |
| spellingShingle | Meijing Yi Meijing Yi Silan Chen Silan Chen Xinying Yi Xinying Yi Fan Zhang Fan Zhang Xuan Zhou Xuan Zhou Meiyan Zeng Houpan Song Houpan Song Helicobacter pylori infection process: from the molecular world to clinical treatment Frontiers in Microbiology Helicobacter pylori pathogenic mechanism treatment antibiotic resistance probiotics |
| title | Helicobacter pylori infection process: from the molecular world to clinical treatment |
| title_full | Helicobacter pylori infection process: from the molecular world to clinical treatment |
| title_fullStr | Helicobacter pylori infection process: from the molecular world to clinical treatment |
| title_full_unstemmed | Helicobacter pylori infection process: from the molecular world to clinical treatment |
| title_short | Helicobacter pylori infection process: from the molecular world to clinical treatment |
| title_sort | helicobacter pylori infection process from the molecular world to clinical treatment |
| topic | Helicobacter pylori pathogenic mechanism treatment antibiotic resistance probiotics |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1541140/full |
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