Discovery of functional factorless internal ribosome entry site-like structures through virome mining.

Discovery of functional factorless internal ribosome entry site-like structures through virome mining.

All viruses must co-opt the host translational machinery for viral protein synthesis. The dicistrovirus intergenic region internal ribosome entry site (IGR-IRES) utilizes the most streamlined translation mechanism by adopting a triple pseudoknot structure that directly recruits and binds within the...

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Main Authors: Subash Chapagain, Nicolas Salcedo-Porras, Amir Abdolahzadeh, Yaohua Zhang, Higor Sette Pereira, Stephane Flibotte, Kevin Low, Christina Young, Yuhang Wu, Shao Wang, Soh Ishiguro, Nozomu Yachie, Trushar Patel, Artem Babaian, Eric Jan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013255
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