Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV
Photoaging, the premature aging of skin due to chronic ultraviolet (UV) exposure, is a growing concern in dermatology and cosmetic science. While UV radiation is known to induce DNA damage, oxidative stress, and inflammation in skin cells, recent research unveils a promising countermeasure: autophag...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1562845/full |
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| author | Zhongsong Zhang Run Tan Run Tan Zuanyu Xiong Yanyan Feng Yanyan Feng Long Chen |
| author_facet | Zhongsong Zhang Run Tan Run Tan Zuanyu Xiong Yanyan Feng Yanyan Feng Long Chen |
| author_sort | Zhongsong Zhang |
| collection | DOAJ |
| description | Photoaging, the premature aging of skin due to chronic ultraviolet (UV) exposure, is a growing concern in dermatology and cosmetic science. While UV radiation is known to induce DNA damage, oxidative stress, and inflammation in skin cells, recent research unveils a promising countermeasure: autophagy. This review explores the intricate relationship between autophagy and photoaging, highlighting how this cellular recycling process can mitigate UV-induced damage. We begin by examining the differential impacts of UVA and UVB radiation on skin cells and the role of oxidative stress in accelerating photoaging. Next, we delve into the molecular mechanisms of autophagy, including its various forms and regulatory pathways. Central to this review is the discussion of autophagy’s protective functions, such as the clearance of damaged organelles and proteins, and its role in maintaining genomic integrity. Furthermore, we address the current challenges in harnessing autophagy for therapeutic purposes, including the need for selective autophagy inducers and a deeper understanding of its context-dependent effects. By synthesizing recent advancements and proposing future research directions, this review underscores the potential of autophagy modulation as a novel strategy to prevent and treat photoaging. This comprehensive analysis aims to inspire further investigation into autophagy-based interventions, offering new hope for preserving skin health in the face of environmental stressors. |
| format | Article |
| id | doaj-art-64eee337c2e94987b72f340fc9da69f1 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-64eee337c2e94987b72f340fc9da69f12025-08-20T03:52:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15628451562845Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UVZhongsong Zhang0Run Tan1Run Tan2Zuanyu Xiong3Yanyan Feng4Yanyan Feng5Long Chen6School of Basic Medical Sciences, Chengdu Medical College, Chengdu, ChinaDepartment of Dermatology, Chengdu Second People‘s Hospital, Chengdu, Sichuan Province, ChinaSchool of Clinical Medicine, Chengdu Medical College, Chengdu, ChinaDepartment of Medical Aesthetics, Nanbu People‘s Hospital, Nanchong, ChinaDepartment of Dermatology, Chengdu Second People‘s Hospital, Chengdu, Sichuan Province, ChinaSchool of Clinical Medicine, Chengdu Medical College, Chengdu, ChinaSchool of Basic Medical Sciences, Chengdu Medical College, Chengdu, ChinaPhotoaging, the premature aging of skin due to chronic ultraviolet (UV) exposure, is a growing concern in dermatology and cosmetic science. While UV radiation is known to induce DNA damage, oxidative stress, and inflammation in skin cells, recent research unveils a promising countermeasure: autophagy. This review explores the intricate relationship between autophagy and photoaging, highlighting how this cellular recycling process can mitigate UV-induced damage. We begin by examining the differential impacts of UVA and UVB radiation on skin cells and the role of oxidative stress in accelerating photoaging. Next, we delve into the molecular mechanisms of autophagy, including its various forms and regulatory pathways. Central to this review is the discussion of autophagy’s protective functions, such as the clearance of damaged organelles and proteins, and its role in maintaining genomic integrity. Furthermore, we address the current challenges in harnessing autophagy for therapeutic purposes, including the need for selective autophagy inducers and a deeper understanding of its context-dependent effects. By synthesizing recent advancements and proposing future research directions, this review underscores the potential of autophagy modulation as a novel strategy to prevent and treat photoaging. This comprehensive analysis aims to inspire further investigation into autophagy-based interventions, offering new hope for preserving skin health in the face of environmental stressors.https://www.frontiersin.org/articles/10.3389/fphar.2025.1562845/fullphotoagingautophagyUVROSskin aging |
| spellingShingle | Zhongsong Zhang Run Tan Run Tan Zuanyu Xiong Yanyan Feng Yanyan Feng Long Chen Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV Frontiers in Pharmacology photoaging autophagy UV ROS skin aging |
| title | Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV |
| title_full | Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV |
| title_fullStr | Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV |
| title_full_unstemmed | Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV |
| title_short | Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV |
| title_sort | dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by uv |
| topic | photoaging autophagy UV ROS skin aging |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1562845/full |
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