The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel
Abstract Background Dental caries, also known as tooth decay or cavity formation, is one of the world’s most widespread dental conditions. It is a plaque-related infection caused mainly by Streptococcus mutans. People have relied on several plant species to treat oral infections; Heteropyxis natalen...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | BMC Complementary Medicine and Therapies |
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| Online Access: | https://doi.org/10.1186/s12906-024-04707-8 |
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| author | Cynthia J. Henley-Smith Anna-Mari Kok Francien S. Botha Chantelle Baker Namrita Lall |
| author_facet | Cynthia J. Henley-Smith Anna-Mari Kok Francien S. Botha Chantelle Baker Namrita Lall |
| author_sort | Cynthia J. Henley-Smith |
| collection | DOAJ |
| description | Abstract Background Dental caries, also known as tooth decay or cavity formation, is one of the world’s most widespread dental conditions. It is a plaque-related infection caused mainly by Streptococcus mutans. People have relied on several plant species to treat oral infections; Heteropyxis natalensis, for example, has been used to treat toothache and gum infections. Methods In this study, the antimicrobial and anti-adherence properties of H. natalensis and Camellia sinensis, as well as tea tree and peppermint essential oils were investigated on tooth enamel. Results The bacterial load of S. mutans was reduced by approximately two orders of a magnitude after 48 h, with a lesser extent on the commensal bacteria, Lactobacillus paracasei. Scanning electron micrographs of enamel blocks showed a reduction in the attachment and chain formation of S. mutans and degraded cell morphology. Lastly, the combination and each component individually, showed low to no cellular toxicity when tested on human macrophages. Conclusions This is the first report of this polyherbal regarding its selectivity and potential prevention of dental caries. |
| format | Article |
| id | doaj-art-64ed6c565be7407db2dd157fc7fd9f99 |
| institution | OA Journals |
| issn | 2662-7671 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj-art-64ed6c565be7407db2dd157fc7fd9f992025-08-20T02:33:00ZengBMCBMC Complementary Medicine and Therapies2662-76712024-11-012411810.1186/s12906-024-04707-8The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamelCynthia J. Henley-Smith0Anna-Mari Kok1Francien S. Botha2Chantelle Baker3Namrita Lall4Department of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of PretoriaDepartment of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of PretoriaElectron Microscope Unit, Sefako Makgatho Health Sciences UniversityElectron Microscope Unit, Sefako Makgatho Health Sciences UniversityDepartment of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of PretoriaAbstract Background Dental caries, also known as tooth decay or cavity formation, is one of the world’s most widespread dental conditions. It is a plaque-related infection caused mainly by Streptococcus mutans. People have relied on several plant species to treat oral infections; Heteropyxis natalensis, for example, has been used to treat toothache and gum infections. Methods In this study, the antimicrobial and anti-adherence properties of H. natalensis and Camellia sinensis, as well as tea tree and peppermint essential oils were investigated on tooth enamel. Results The bacterial load of S. mutans was reduced by approximately two orders of a magnitude after 48 h, with a lesser extent on the commensal bacteria, Lactobacillus paracasei. Scanning electron micrographs of enamel blocks showed a reduction in the attachment and chain formation of S. mutans and degraded cell morphology. Lastly, the combination and each component individually, showed low to no cellular toxicity when tested on human macrophages. Conclusions This is the first report of this polyherbal regarding its selectivity and potential prevention of dental caries.https://doi.org/10.1186/s12906-024-04707-8Anti-adherenceCariesHeteropyxis natalensisLactobacillus paracaseiOral cavityStreptococcus mutans |
| spellingShingle | Cynthia J. Henley-Smith Anna-Mari Kok Francien S. Botha Chantelle Baker Namrita Lall The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel BMC Complementary Medicine and Therapies Anti-adherence Caries Heteropyxis natalensis Lactobacillus paracasei Oral cavity Streptococcus mutans |
| title | The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel |
| title_full | The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel |
| title_fullStr | The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel |
| title_full_unstemmed | The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel |
| title_short | The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel |
| title_sort | effect of a poly herbal plant extract on the adhesion of streptococcus mutans to tooth enamel |
| topic | Anti-adherence Caries Heteropyxis natalensis Lactobacillus paracasei Oral cavity Streptococcus mutans |
| url | https://doi.org/10.1186/s12906-024-04707-8 |
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